DegronMD - O94989(ARHGEF15)

FUNCTION: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.

GO - Biological processes (BP): activation of GTPase activity [GO:0090630]; negative regulation of synapse maturation [GO:2000297]; positive regulation of stress fiber assembly [GO:0051496]; regulation of catalytic activity [GO:0050790]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morph... View more >>

GO - Molecular function (MF): GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R272C	TCGA-06-5416	GBM	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272C	DO10880	GBM	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272H	TCGA-E6-A1LX	UCEC	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.R272H	DO222884	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.R272H	DO41020	UCEC	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.P54A	TCGA-23-1117	OV	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7503
p.P54A	DO30830	OV	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7503
p.P56Q	TCGA-IB-7651	PAAD	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7035
p.P56Q	DO46657	PAAD	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7035
p.P56S	TCGA-FR-A8YE	SKCM	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6752
p.P56S	DO50303	SKCM	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6752
p.M57I	DO229029	LICA	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6507
p.L277P	DO227999	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229010	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229013	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229016	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229003	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229005	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229473	LAML	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L274P	DO219881	SKCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471

Showing 1 to 20 of 78 entries

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No resistance data available for this Degron.

Kaplan plot for ARHGEF15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF15

UniProt ID: O94989

Entrez ID: 22899

Protein name: Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ARHGEF15 in