DegronMD - O94989(ARHGEF15)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R272C	TCGA-06-5416	GBM	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272C	DO10880	GBM	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.P54A	TCGA-23-1117	OV	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7503
p.P54A	DO30830	OV	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7503
p.P110T	TCGA-60-2713	LUSC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.P110T	DO26476	LUSC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.E45D	TCGA-60-2722	LUSC	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.0833
p.E45D	DO26798	LUSC	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.0833
p.R267H	TCGA-AA-A00N	COAD	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.R267H	DO9876	COAD	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.P324A	TCGA-AC-A23H	BRCA	TCGA	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation altering degron motif	0.6392
p.P324A	DO2401	BRCA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation altering degron motif	0.6392
p.P91S	TCGA-AP-A0LD	UCEC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.25
p.P91S	DO41578	UCEC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.25
p.S96R	TCGA-AR-A1AJ	BRCA	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation altering degron motif	0.6316
p.S96R	DO4062	BRCA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation altering degron motif	0.6316
p.Q88H	TCGA-B5-A1MR	UCEC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1667
p.Q88H	DO41758	UCEC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1667
p.S90F	TCGA-BR-6452	STAD	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.2222
p.S90F	DO38404	STAD	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.2222
p.S107F	TCGA-C8-A12T	BRCA	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1667
p.S107F	DO5507	BRCA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1667
p.S107F	ACH-001411	Bladder Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1667
p.D52Y	TCGA-CA-6717	COAD	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.2778
p.D52Y	DO8264	COAD	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.2778
p.L85I	TCGA-CK-5916	COAD	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.L85I	DO8786	COAD	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.L85I	SIDM00151	Ovarian Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.L85I	ACH-000966	Ovarian Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.L85I	IGROV-1	ovary	COSMIC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.R48Q	TCGA-CV-6960	HNSC	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.1667
p.R48Q	DO14156	HNSC	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.1667
p.R48Q	SIDM00499	Prostate Carcinoma	GDSC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.1667
p.R48Q	ACH-000956	Prostate Cancer	CCLE	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.1667
p.R48Q	22RV1	prostate	COSMIC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.1667
p.R272H	TCGA-E6-A1LX	UCEC	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.R272H	DO222884	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.R272H	DO41020	UCEC	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8244
p.P56S	TCGA-FR-A8YE	SKCM	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6752
p.P56S	DO50303	SKCM	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6752
p.P110S	TCGA-FS-A1ZA	SKCM	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.P110S	DO37551	SKCM	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.0833
p.P56Q	TCGA-IB-7651	PAAD	TCGA	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7035
p.P56Q	DO46657	PAAD	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.7035
p.R285C	TCGA-VS-A8EC	CESC	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1667
p.R285C	DO51618	CESC	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1667
p.S109F	TCGA-YD-A89C	SKCM	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation blocking phosphorylation signal	0.5556
p.S109F	DO219501	SKCM	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation blocking phosphorylation signal	0.5556
p.L277P	DO227999	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229010	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229013	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229016	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229003	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229005	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L277P	DO229473	LAML	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.R285H	DO50447	ESAD	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1667
p.E317K	DO222452	ESCA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2778
p.M57I	DO229029	LICA	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation altering degron motif	0.6507
p.V261I	DO45299	LIRI	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.0556
p.V327M	DO220878	MELA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.3056
p.P100S	DO220886	MELA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation altering degron motif	0.5641
p.P60L	DO220887	MELA	ICGC	PTPMCT	DEG_SCF_FBW7_1	54:59	Mutation rewiring degron network	0.3056
p.P281S	DO222875	MELA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2778
p.E336D	DO46859	RECA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.0556
p.L274P	DO219881	SKCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.L274P	DO218904	SKCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6471
p.E328K	SIDM01169	Ovarian Carcinoma	GDSC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2778
p.E328K	ACH-000885	Ovarian Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2778
p.E328K	TOV-21G	ovary	COSMIC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2778
p.D86N	SIDM00454	Rhabdomyosarcoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1111
p.A108T	SIDM00789	Colorectal Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1389
p.A108T	SIDM00217	Colorectal Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1389
p.P315S	SIDM00719	Small Cell Lung Carcinoma	GDSC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2222
p.P315S	ACH-001364	Lung Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2222
p.P315S	NCI-H345	lung	COSMIC	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.2222
p.A108V	SIDM01587	Bladder Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1389
p.A108V	ACH-000753	Bladder Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	94:101	Mutation rewiring degron network	0.1389
p.D313N	ACH-002669	Colon/Colorectal Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	319:326	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF15

UniProt ID: O94989

Entrez ID: 22899

Protein name: Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF15 in