DegronMD

Uniprot ID: O94989

Source protein: Rho guanine nucleotide exchange factor 15

Source gene: ARHGEF15

Class: DEG_SCF_FBW7_1

Location: 319:326

E3 ligase: FBXW7

DEGRON score: 0.8462

ASA_SCORE: 83.85

COIL: 0.9329

CONS_SCORE: 0.457

DSS_SCORE: 0.9058

HELIX: 0.0373

FCONS_SCORE: 0.9396

RIG_SCORE: 0.5918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P324A	TCGA-AC-A23H	BRCA	TCGA	PQNTPPAT	DEG_SCF_FBW7_1	0.6392
p.P324A	DO2401	BRCA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	0.6392
p.E317K	DO222452	ESCA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	0.2778
p.V327M	DO220878	MELA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	0.3056
p.E336D	DO46859	RECA	ICGC	PQNTPPAT	DEG_SCF_FBW7_1	0.0556
p.E328K	SIDM01169	Ovarian Carcinoma	GDSC	PQNTPPAT	DEG_SCF_FBW7_1	0.2778
p.E328K	ACH-000885	Ovarian Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	0.2778
p.E328K	TOV-21G	ovary	COSMIC	PQNTPPAT	DEG_SCF_FBW7_1	0.2778
p.P315S	SIDM00719	Small Cell Lung Carcinoma	GDSC	PQNTPPAT	DEG_SCF_FBW7_1	0.2222
p.P315S	ACH-001364	Lung Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	0.2222
p.P315S	NCI-H345	lung	COSMIC	PQNTPPAT	DEG_SCF_FBW7_1	0.2222
p.D313N	ACH-002669	Colon/Colorectal Cancer	CCLE	PQNTPPAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94989	Rho guanine nucleotide exchange factor 15	DEG_SCF_FBW7_1	319:326	PQNTPPAT	FBXW7	0.8462	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons