DegronMD

Uniprot ID: O94989

Source protein: Rho guanine nucleotide exchange factor 15

Source gene: ARHGEF15

Class: DEG_SCF_FBW7_1

Location: 54:59

E3 ligase: FBXW7

DEGRON score: 0.9926

ASA_SCORE: 75.4667

COIL: 0.9367

CONS_SCORE: 0.4652

DSS_SCORE: 0.5996

HELIX: 0.0173

FCONS_SCORE: 1.0123

RIG_SCORE: 0.664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P54A	TCGA-23-1117	OV	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.7503
p.P54A	DO30830	OV	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.7503
p.E45D	TCGA-60-2722	LUSC	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.0833
p.E45D	DO26798	LUSC	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.0833
p.D52Y	TCGA-CA-6717	COAD	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.2778
p.D52Y	DO8264	COAD	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.2778
p.R48Q	TCGA-CV-6960	HNSC	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.1667
p.R48Q	DO14156	HNSC	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.1667
p.R48Q	SIDM00499	Prostate Carcinoma	GDSC	PTPMCT	DEG_SCF_FBW7_1	0.1667
p.R48Q	ACH-000956	Prostate Cancer	CCLE	PTPMCT	DEG_SCF_FBW7_1	0.1667
p.R48Q	22RV1	prostate	COSMIC	PTPMCT	DEG_SCF_FBW7_1	0.1667
p.P56S	TCGA-FR-A8YE	SKCM	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.6752
p.P56S	DO50303	SKCM	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.6752
p.P56Q	TCGA-IB-7651	PAAD	TCGA	PTPMCT	DEG_SCF_FBW7_1	0.7035
p.P56Q	DO46657	PAAD	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.7035
p.M57I	DO229029	LICA	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.6507
p.P60L	DO220887	MELA	ICGC	PTPMCT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94989	Rho guanine nucleotide exchange factor 15	DEG_SCF_FBW7_1	54:59	PTPMCT	FBXW7	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons