DegronMD

Uniprot ID: O94989

Source protein: Rho guanine nucleotide exchange factor 15

Source gene: ARHGEF15

Class: DEG_SCF_FBW7_1

Location: 94:101

E3 ligase: FBXW7

DEGRON score: 0.964

ASA_SCORE: 92.675

COIL: 0.9725

CONS_SCORE: 0.4613

DSS_SCORE: 0.8143

HELIX: 0.0116

FCONS_SCORE: 0.9818

RIG_SCORE: 0.4369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110T	TCGA-60-2713	LUSC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.P110T	DO26476	LUSC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.P91S	TCGA-AP-A0LD	UCEC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.25
p.P91S	DO41578	UCEC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.25
p.S96R	TCGA-AR-A1AJ	BRCA	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.6316
p.S96R	DO4062	BRCA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.6316
p.Q88H	TCGA-B5-A1MR	UCEC	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.1667
p.Q88H	DO41758	UCEC	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.1667
p.S90F	TCGA-BR-6452	STAD	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.2222
p.S90F	DO38404	STAD	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.2222
p.S107F	TCGA-C8-A12T	BRCA	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.1667
p.S107F	DO5507	BRCA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.1667
p.S107F	ACH-001411	Bladder Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	0.1667
p.L85I	TCGA-CK-5916	COAD	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L85I	DO8786	COAD	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L85I	SIDM00151	Ovarian Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L85I	ACH-000966	Ovarian Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L85I	IGROV-1	ovary	COSMIC	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.P110S	TCGA-FS-A1ZA	SKCM	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.P110S	DO37551	SKCM	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.0833
p.S109F	TCGA-YD-A89C	SKCM	TCGA	PSSTPTPS	DEG_SCF_FBW7_1	0.5556
p.S109F	DO219501	SKCM	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.5556
p.P100S	DO220886	MELA	ICGC	PSSTPTPS	DEG_SCF_FBW7_1	0.5641
p.D86N	SIDM00454	Rhabdomyosarcoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	0.1111
p.A108T	SIDM00789	Colorectal Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	0.1389
p.A108T	SIDM00217	Colorectal Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	0.1389
p.A108V	SIDM01587	Bladder Carcinoma	GDSC	PSSTPTPS	DEG_SCF_FBW7_1	0.1389
p.A108V	ACH-000753	Bladder Cancer	CCLE	PSSTPTPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94989	Rho guanine nucleotide exchange factor 15	DEG_SCF_FBW7_1	94:101	PSSTPTPS	FBXW7	0.964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPTPS

Degron related mutations and impact score

Drug responses associated with ARHGEF15 mutations

All proteins holding degron of PSSTPTPS