DegronMD

Uniprot ID: P17987

Source protein: T-complex protein 1 subunit alpha

Source gene: TCP1

Class: DEG_APCC_DBOX_1

Location: 479:487

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5724

ASA_SCORE: 71.9222

COIL: 0.526

CONS_SCORE: 0.3517

DSS_SCORE: 0.3699

HELIX: 0.1673

FCONS_SCORE: 0.7918

RIG_SCORE: 0.8051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R480C	TCGA-A6-A565	COAD	TCGA	ERKNLKWIG	DEG_APCC_DBOX_1	0.8301
p.R480C	DO44090	COAD	ICGC	ERKNLKWIG	DEG_APCC_DBOX_1	0.8301
p.R496Q	TCGA-B5-A11E	UCEC	TCGA	ERKNLKWIG	DEG_APCC_DBOX_1	0.0833
p.R496Q	DO41644	UCEC	ICGC	ERKNLKWIG	DEG_APCC_DBOX_1	0.0833
p.A474P	SIDM00659	Glioblastoma	GDSC	ERKNLKWIG	DEG_APCC_DBOX_1	0.1944
p.A474P	ACH-000152	Brain Cancer	CCLE	ERKNLKWIG	DEG_APCC_DBOX_1	0.1944
p.A474P	ACH-001118	Brain Cancer	CCLE	ERKNLKWIG	DEG_APCC_DBOX_1	0.1944
p.A474P	M059J	central_nervous_system	COSMIC	ERKNLKWIG	DEG_APCC_DBOX_1	0.1944
p.N482H	SIDM01611	Endometrial Carcinoma	GDSC	ERKNLKWIG	DEG_APCC_DBOX_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17987	T-complex protein 1 subunit alpha	DEG_APCC_DBOX_1	479:487	ERKNLKWIG	APC,CDC20,FZR1	0.5724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons