DegronMD - P17987(TCP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R480C	TCGA-A6-A565	COAD	TCGA	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation altering degron motif	0.8301
p.R480C	DO44090	COAD	ICGC	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation altering degron motif	0.8301
p.P4S	TCGA-AA-3811	COAD	TCGA	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.3056
p.P4S	DO7962	COAD	ICGC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.3056
p.R526Q	TCGA-AJ-A3EK	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R526Q	TCGA-D1-A17Q	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R526Q	TCGA-E6-A1LX	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R526Q	DO41020	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R526Q	DO41584	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R526Q	DO41903	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1944
p.R496Q	TCGA-B5-A11E	UCEC	TCGA	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.0833
p.R496Q	DO41644	UCEC	ICGC	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.0833
p.G9C	TCGA-D3-A3C6	SKCM	TCGA	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation altering degron motif	0.6489
p.G9C	DO37507	SKCM	ICGC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation altering degron motif	0.6489
p.R18S	TCGA-EE-A2GT	SKCM	TCGA	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.R18S	DO37946	SKCM	ICGC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1111
p.E546K	TCGA-UF-A719	HNSC	TCGA	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0556
p.E546K	DO52105	HNSC	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.0556
p.D529Y	DO222884	COCA	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.2778
p.Q20E	DO229493	LAML	ICGC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.0556
p.I527S	DO231573	LINC	ICGC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.2222
p.G9S	DO229135	LMS	ICGC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation altering degron motif	0.5882
p.I17M	SIDM00777	Colorectal Carcinoma	GDSC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1389
p.I17M	ACH-000360	Colon/Colorectal Cancer	CCLE	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1389
p.I17M	NCI-H508	large intestine	COSMIC	LSVFGD	LIG_APCC_ABBA_1	5:10	Mutation rewiring degron network	0.1389
p.A474P	SIDM00659	Glioblastoma	GDSC	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.1944
p.A474P	ACH-000152	Brain Cancer	CCLE	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.1944
p.A474P	ACH-001118	Brain Cancer	CCLE	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.1944
p.A474P	M059J	central nervous system	COSMIC	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation rewiring degron network	0.1944
p.I524L	SIDM00266	Ewing's Sarcoma	GDSC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.I524L	ACH-002103	Bone Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.I524L	ES1	bone	COSMIC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1389
p.D528H	SIDM01043	Other Sarcomas	GDSC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.D528H	ACH-000913	Endometrial/Uterine Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.D528H	ESS-1	endometrium	COSMIC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.25
p.T523I	SIDM00150	Colorectal Carcinoma	GDSC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.T523I	ACH-000969	Colon/Colorectal Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.T523I	KM12	large intestine	COSMIC	IKLHPE	LIG_APCC_ABBA_1	531:536	Mutation rewiring degron network	0.1111
p.N482H	SIDM01611	Endometrial Carcinoma	GDSC	ERKNLKWIG	DEG_APCC_DBOX_1	479:487	Mutation altering degron motif	0.6312

Kaplan plot for TCP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCP1

UniProt ID: P17987

Entrez ID: 6950

Protein name: T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCP1 in