DegronMD

Uniprot ID: P17987

Source protein: T-complex protein 1 subunit alpha

Source gene: TCP1

Class: LIG_APCC_ABBA_1

Location: 5:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9676

ASA_SCORE: 70.0667

COIL: 0.7623

CONS_SCORE: 0.3595

DSS_SCORE: 0.6542

HELIX: 0.1357

FCONS_SCORE: 0.9208

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4S	TCGA-AA-3811	COAD	TCGA	LSVFGD	LIG_APCC_ABBA_1	0.3056
p.P4S	DO7962	COAD	ICGC	LSVFGD	LIG_APCC_ABBA_1	0.3056
p.G9C	TCGA-D3-A3C6	SKCM	TCGA	LSVFGD	LIG_APCC_ABBA_1	0.6489
p.G9C	DO37507	SKCM	ICGC	LSVFGD	LIG_APCC_ABBA_1	0.6489
p.R18S	TCGA-EE-A2GT	SKCM	TCGA	LSVFGD	LIG_APCC_ABBA_1	0.1111
p.R18S	DO37946	SKCM	ICGC	LSVFGD	LIG_APCC_ABBA_1	0.1111
p.Q20E	DO229493	LAML	ICGC	LSVFGD	LIG_APCC_ABBA_1	0.0556
p.G9S	DO229135	LMS	ICGC	LSVFGD	LIG_APCC_ABBA_1	0.5882
p.I17M	SIDM00777	Colorectal Carcinoma	GDSC	LSVFGD	LIG_APCC_ABBA_1	0.1389
p.I17M	ACH-000360	Colon/Colorectal Cancer	CCLE	LSVFGD	LIG_APCC_ABBA_1	0.1389
p.I17M	NCI-H508	large_intestine	COSMIC	LSVFGD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17987	T-complex protein 1 subunit alpha	LIG_APCC_ABBA_1	5:10	LSVFGD	APC,CDC20,FZR1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons