DegronMD

Uniprot ID: P17987

Source protein: T-complex protein 1 subunit alpha

Source gene: TCP1

Class: LIG_APCC_ABBA_1

Location: 531:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 84.0167

COIL: 0.7398

CONS_SCORE: 0.5061

DSS_SCORE: 0.2879

HELIX: 0.2143

FCONS_SCORE: 1.0497

RIG_SCORE: 0.7738

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R526Q	TCGA-AJ-A3EK	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.R526Q	TCGA-D1-A17Q	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.R526Q	TCGA-E6-A1LX	UCEC	TCGA	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.R526Q	DO41020	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.R526Q	DO41584	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.R526Q	DO41903	UCEC	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.1944
p.E546K	TCGA-UF-A719	HNSC	TCGA	IKLHPE	LIG_APCC_ABBA_1	0.0556
p.E546K	DO52105	HNSC	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.0556
p.D529Y	DO222884	COCA	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.2778
p.I527S	DO231573	LINC	ICGC	IKLHPE	LIG_APCC_ABBA_1	0.2222
p.I524L	SIDM00266	Ewing's Sarcoma	GDSC	IKLHPE	LIG_APCC_ABBA_1	0.1389
p.I524L	ACH-002103	Bone Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	0.1389
p.I524L	ES1	bone	COSMIC	IKLHPE	LIG_APCC_ABBA_1	0.1389
p.D528H	SIDM01043	Other Sarcomas	GDSC	IKLHPE	LIG_APCC_ABBA_1	0.25
p.D528H	ACH-000913	Endometrial/Uterine Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	0.25
p.D528H	ESS-1	endometrium	COSMIC	IKLHPE	LIG_APCC_ABBA_1	0.25
p.T523I	SIDM00150	Colorectal Carcinoma	GDSC	IKLHPE	LIG_APCC_ABBA_1	0.1111
p.T523I	ACH-000969	Colon/Colorectal Cancer	CCLE	IKLHPE	LIG_APCC_ABBA_1	0.1111
p.T523I	KM12	large_intestine	COSMIC	IKLHPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17987	T-complex protein 1 subunit alpha	LIG_APCC_ABBA_1	531:536	IKLHPE	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons