DegronMD

Uniprot ID: Q969S9

Source protein: Ribosome-releasing factor 2, mitochondrial

Source gene: GFM2

Class: DEG_APCC_DBOX_1

Location: 257:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6398

ASA_SCORE: 87.6889

COIL: 0.4903

CONS_SCORE: 0.4735

DSS_SCORE: 0.4387

HELIX: 0.1846

FCONS_SCORE: 1.2013

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E257D	TCGA-CN-A63Y	HNSC	TCGA	ERKPLLEMN	DEG_APCC_DBOX_1	0.5647
p.E257D	DO44422	HNSC	ICGC	ERKPLLEMN	DEG_APCC_DBOX_1	0.5647
p.M264I	DO1094	BRCA	ICGC	ERKPLLEMN	DEG_APCC_DBOX_1	0.6507
p.K259N	DO229248	THCA	ICGC	ERKPLLEMN	DEG_APCC_DBOX_1	0.5806
p.P267L	SIDM00181	Bladder Carcinoma	GDSC	ERKPLLEMN	DEG_APCC_DBOX_1	0.2778
p.P267L	ACH-002266	Bladder Cancer	CCLE	ERKPLLEMN	DEG_APCC_DBOX_1	0.2778
p.P267L	LB831-BLC	urinary_tract	COSMIC	ERKPLLEMN	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969S9	Ribosome-releasing factor 2, mitochondrial	DEG_APCC_DBOX_1	257:265	ERKPLLEMN	APC,CDC20,FZR1	0.6398	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons