DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERKRLKNIS
Uniprot ID:
Q9H967
Source protein:
WD repeat-containing protein 76
Source gene:
WDR76
Class:
DEG_APCC_DBOX_1
Location:
163:171
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9661
ASA_SCORE:
87.2
COIL:
0.0923
CONS_SCORE:
0.4608
DSS_SCORE:
0.356
HELIX:
0.9102
FCONS_SCORE:
1.3882
RIG_SCORE:
0.7566
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A174T
TCGA-A5-A0G2
UCEC
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.A174T
TCGA-AX-A1CE
UCEC
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.A174T
TCGA-BR-7851
STAD
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.A174T
SIDM00142
Endometrial Carcinoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.A174T
SIDM01619
Endometrial Carcinoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.A174T
COLO-684
endometrium
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.25
p.S157L
TCGA-B5-A11Y
UCEC
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.1667
p.E163K
TCGA-BT-A2LB
BLCA
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.591
p.S171L
TCGA-K4-A54R
BLCA
TCGA
ERKRLKNIS
DEG_APCC_DBOX_1
0.7667
p.R155Q
DO9002
COAD
ICGC
ERKRLKNIS
DEG_APCC_DBOX_1
0.1111
p.P167T
DO52409
UCEC
ICGC
ERKRLKNIS
DEG_APCC_DBOX_1
0.7031
p.S179F
SIDM00422
Hodgkin's Lymphoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.5556
p.S179F
SUP-HD1
haematopoietic_and_lymphoid_tissue
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.5556
p.K168R
SIDM01082
Oral Cavity Carcinoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.6126
p.K168R
SCC-25
upper_aerodigestive_tract
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.6126
p.K165T
SIDM00956
Esophageal Squamous Cell Carcinoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.6195
p.K165T
SIDM01752
Pancreatic Carcinoma
GDSC
ERKRLKNIS
DEG_APCC_DBOX_1
0.6195
p.S162L
ACH-000352
Breast Cancer
CCLE
ERKRLKNIS
DEG_APCC_DBOX_1
0.3056
p.S162L
HCC1428
breast
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.3056
p.L175F
ACH-002282
Neuroblastoma
CCLE
ERKRLKNIS
DEG_APCC_DBOX_1
0.2222
p.L175F
NB17
autonomic_ganglia
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.2222
p.L175F
NBsusSR
autonomic_ganglia
COSMIC
ERKRLKNIS
DEG_APCC_DBOX_1
0.2222
Drug responses associated with WDR76 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERKRLKNIS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H967
WD repeat-containing protein 76
DEG_APCC_DBOX_1
163:171
ERKRLKNIS
APC,CDC20,FZR1
0.9661
More...