DegronMD

Uniprot ID: Q9H967

Source protein: WD repeat-containing protein 76

Source gene: WDR76

Class: DEG_APCC_DBOX_1

Location: 163:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9661

ASA_SCORE: 87.2

COIL: 0.0923

CONS_SCORE: 0.4608

DSS_SCORE: 0.356

HELIX: 0.9102

FCONS_SCORE: 1.3882

RIG_SCORE: 0.7566

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171L	TCGA-K4-A54R	BLCA	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.7667
p.P167T	DO52409	UCEC	ICGC	ERKRLKNIS	DEG_APCC_DBOX_1	0.7031
p.K165T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.6195
p.K165T	SIDM01752	Pancreatic Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.6195
p.K168R	SIDM01082	Oral Cavity Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.6126
p.K168R	SCC-25	upper_aerodigestive_tract	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.6126
p.E163K	TCGA-BT-A2LB	BLCA	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.591
p.S179F	SIDM00422	Hodgkin's Lymphoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.5556
p.S179F	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.5556
p.S162L	ACH-000352	Breast Cancer	CCLE	ERKRLKNIS	DEG_APCC_DBOX_1	0.3056
p.S162L	HCC1428	breast	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.3056
p.A174T	TCGA-A5-A0G2	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.A174T	TCGA-AX-A1CE	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.A174T	TCGA-BR-7851	STAD	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.A174T	SIDM00142	Endometrial Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.A174T	SIDM01619	Endometrial Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.A174T	COLO-684	endometrium	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.25
p.L175F	ACH-002282	Neuroblastoma	CCLE	ERKRLKNIS	DEG_APCC_DBOX_1	0.2222
p.L175F	NB17	autonomic_ganglia	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.2222
p.L175F	NBsusSR	autonomic_ganglia	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	0.2222
p.S157L	TCGA-B5-A11Y	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	0.1667
p.R155Q	DO9002	COAD	ICGC	ERKRLKNIS	DEG_APCC_DBOX_1	0.1111

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H967	WD repeat-containing protein 76	DEG_APCC_DBOX_1	163:171	ERKRLKNIS	APC,CDC20,FZR1	0.9661	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons