DegronMD - Q9H967(WDR76)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A174T	TCGA-A5-A0G2	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.A174T	TCGA-AX-A1CE	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.A174T	TCGA-BR-7851	STAD	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.A174T	SIDM00142	Endometrial Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.A174T	SIDM01619	Endometrial Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.A174T	COLO-684	endometrium	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.L35V	TCGA-A8-A07U	BRCA	TCGA	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1389
p.S157L	TCGA-B5-A11Y	UCEC	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.E163K	TCGA-BT-A2LB	BLCA	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.591
p.Q18K	TCGA-FS-A1ZP	SKCM	TCGA	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1667
p.Q18K	DO37703	SKCM	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1667
p.S171L	TCGA-K4-A54R	BLCA	TCGA	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7667
p.S38C	DO51891	BLCA	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.0556
p.K19N	DO6308	CESC	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1944
p.R155Q	DO9002	COAD	ICGC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1111
p.K25T	DO222762	COCA	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation altering degron motif	0.7306
p.R16L	DO229038	LICA	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1111
p.T25S	DO45549	LUSC	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation altering degron motif	0.7116
p.V15M	DO47469	SKCM	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.0833
p.S38T	DO38328	STAD	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.0556
p.K18N	DO50075	UCEC	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1667
p.P167T	DO52409	UCEC	ICGC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7031
p.K24T	DO41542	UCEC	ICGC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation altering degron motif	0.7306
p.S179F	SIDM00422	Hodgkin's Lymphoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.5556
p.S179F	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.5556
p.M19I	SIDM00573	Glioblastoma	GDSC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1944
p.M19I	ACH-001606	Brain Cancer	CCLE	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1944
p.M19I	no-11	central nervous system	COSMIC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1944
p.K168R	SIDM01082	Oral Cavity Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.6126
p.K168R	SCC-25	upper aerodigestive tract	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.6126
p.K165T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.6195
p.K165T	SIDM01752	Pancreatic Carcinoma	GDSC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.6195
p.R16Q	SIDM01343	Gastric Carcinoma	GDSC	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1111
p.R16Q	ACH-000764	Gastric Cancer	CCLE	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.1111
p.S162L	ACH-000352	Breast Cancer	CCLE	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.3056
p.S162L	HCC1428	breast	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.3056
p.L175F	ACH-002282	Neuroblastoma	CCLE	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2222
p.L175F	NB17	autonomic ganglia	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2222
p.L175F	NBsusSR	autonomic ganglia	COSMIC	ERKRLKNIS	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2222
p.K23N	ACH-002366	Non-Cancerous	CCLE	YKENQ	DEG_APCC_KENBOX_2	24:28	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR76

UniProt ID: Q9H967

Entrez ID: 79968

Protein name: WD repeat-containing protein 76

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR76 in