DegronMD

Uniprot ID: Q9H967

Source protein: WD repeat-containing protein 76

Source gene: WDR76

Class: DEG_APCC_KENBOX_2

Location: 24:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9598

ASA_SCORE: 108.22

COIL: 0.5626

CONS_SCORE: 0.1653

DSS_SCORE: 0.3583

HELIX: 0.4108

FCONS_SCORE: 1.0496

RIG_SCORE: 0.7804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L35V	TCGA-A8-A07U	BRCA	TCGA	YKENQ	DEG_APCC_KENBOX_2	0.1389
p.Q18K	TCGA-FS-A1ZP	SKCM	TCGA	YKENQ	DEG_APCC_KENBOX_2	0.1667
p.Q18K	DO37703	SKCM	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.1667
p.S38C	DO51891	BLCA	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.0556
p.K19N	DO6308	CESC	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.1944
p.K25T	DO222762	COCA	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.7306
p.R16L	DO229038	LICA	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.1111
p.T25S	DO45549	LUSC	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.7116
p.V15M	DO47469	SKCM	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.0833
p.S38T	DO38328	STAD	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.0556
p.K18N	DO50075	UCEC	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.1667
p.K24T	DO41542	UCEC	ICGC	YKENQ	DEG_APCC_KENBOX_2	0.7306
p.M19I	SIDM00573	Glioblastoma	GDSC	YKENQ	DEG_APCC_KENBOX_2	0.1944
p.M19I	ACH-001606	Brain Cancer	CCLE	YKENQ	DEG_APCC_KENBOX_2	0.1944
p.M19I	no-11	central_nervous_system	COSMIC	YKENQ	DEG_APCC_KENBOX_2	0.1944
p.R16Q	SIDM01343	Gastric Carcinoma	GDSC	YKENQ	DEG_APCC_KENBOX_2	0.1111
p.R16Q	ACH-000764	Gastric Cancer	CCLE	YKENQ	DEG_APCC_KENBOX_2	0.1111
p.K23N	ACH-002366	Non-Cancerous	CCLE	YKENQ	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H967	WD repeat-containing protein 76	DEG_APCC_KENBOX_2	24:28	YKENQ	APC,CDC20,FZR1	0.9598	More...
Q6S8J7	POTE ankyrin domain family member A	DEG_APCC_KENBOX_2	286:290	YKENQ	APC,CDC20,FZR1	0.8045	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons