DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
YKENQ
Uniprot ID:
Q6S8J7
Source protein:
POTE ankyrin domain family member A
Source gene:
POTEA
Class:
DEG_APCC_KENBOX_2
Location:
286:290
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8045
ASA_SCORE:
96.3
COIL:
0.7348
CONS_SCORE:
0.5619
DSS_SCORE:
0.4981
HELIX:
0.226
FCONS_SCORE:
1.1286
RIG_SCORE:
0.6934
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POTEA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of YKENQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H967
WD repeat-containing protein 76
DEG_APCC_KENBOX_2
24:28
YKENQ
APC,CDC20,FZR1
0.9598
More...
Q6S8J7
POTE ankyrin domain family member A
DEG_APCC_KENBOX_2
286:290
YKENQ
APC,CDC20,FZR1
0.8045
More...