DegronMD

Uniprot ID: Q14562

Source protein: ATP-dependent RNA helicase DHX8

Source gene: DHX8

Class: DEG_APCC_DBOX_1

Location: 387:395

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.973

ASA_SCORE: 105.7444

COIL: 0.4361

CONS_SCORE: 0.264

DSS_SCORE: 0.4625

HELIX: 0.5531

FCONS_SCORE: 1.0043

RIG_SCORE: 0.761

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R388C	TCGA-VQ-A8P2	STAD	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	0.8301
p.R388C	DO51761	STAD	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.8301
p.S395F	TCGA-EE-A3JA	SKCM	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	0.7982
p.S395F	DO47625	SKCM	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.7982
p.R388P	DO45185	LIRI	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.7512
p.R393Q	DO234183	ESAD	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.6218
p.R393Q	SIDM01113	Other Sarcomas	GDSC	ERKRLTRIS	DEG_APCC_DBOX_1	0.6218
p.R393Q	ACH-000939	Sarcoma	CCLE	ERKRLTRIS	DEG_APCC_DBOX_1	0.6218
p.R393Q	SK-UT-1	soft_tissue	COSMIC	ERKRLTRIS	DEG_APCC_DBOX_1	0.6218
p.S377G	DO233254	GACA	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.5
p.P379L	TCGA-EE-A2GJ	SKCM	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	0.1111
p.P379L	DO37746	SKCM	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	0.1111
p.P379S	SIDM00852	Glioma	GDSC	ERKRLTRIS	DEG_APCC_DBOX_1	0.1111
p.P379S	ACH-000389	Brain Cancer	CCLE	ERKRLTRIS	DEG_APCC_DBOX_1	0.1111
p.P379S	H4	central_nervous_system	COSMIC	ERKRLTRIS	DEG_APCC_DBOX_1	0.1111

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14562	ATP-dependent RNA helicase DHX8	DEG_APCC_DBOX_1	387:395	ERKRLTRIS	APC,CDC20,FZR1	0.973	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons