DegronMD - Q14562(DHX8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R352Q	TCGA-AA-3510	COAD	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1111
p.R352Q	DO7783	COAD	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1111
p.R352Q	SIDM02035	Colorectal Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1111
p.L346I	TCGA-AX-A2HC	UCEC	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.2778
p.L346I	DO41572	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.2778
p.M335I	TCGA-CV-7440	HNSC	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.2222
p.M335I	DO15078	HNSC	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.2222
p.D345E	TCGA-D1-A1NS	UCEC	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.3056
p.D345E	DO42193	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.3056
p.R351W	TCGA-DC-6683	READ	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1389
p.R351W	DO222817	BTCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1389
p.R351W	DO37018	READ	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.1389
p.D339N	TCGA-DU-6392	LGG	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation altering degron motif	0.5821
p.D339N	DO22237	LGG	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation altering degron motif	0.5821
p.P379L	TCGA-EE-A2GJ	SKCM	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.1111
p.P379L	DO37746	SKCM	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.1111
p.S395F	TCGA-EE-A3JA	SKCM	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.7982
p.S395F	DO47625	SKCM	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.7982
p.L354F	TCGA-LN-A9FP	ESCA	TCGA	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.0556
p.R388C	TCGA-VQ-A8P2	STAD	TCGA	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.8301
p.R388C	DO51761	STAD	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.8301
p.R393Q	DO234183	ESAD	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.6218
p.R393Q	SIDM01113	Other Sarcomas	GDSC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.6218
p.R393Q	ACH-000939	Sarcoma	CCLE	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.6218
p.R393Q	SK-UT-1	soft tissue	COSMIC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.6218
p.S377G	DO233254	GACA	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation blocking phosphorylation signal	0.5
p.D337Y	DO229035	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation rewiring degron network	0.2778
p.R388P	DO45185	LIRI	ICGC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation altering degron motif	0.7512
p.G343V	SIDM02026	Colorectal Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	339:344	Mutation altering degron motif	0.7532
p.P379S	SIDM00852	Glioma	GDSC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.1111
p.P379S	ACH-000389	Brain Cancer	CCLE	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.1111
p.P379S	H4	central nervous system	COSMIC	ERKRLTRIS	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.1111

Kaplan plot for DHX8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX8

UniProt ID: Q14562

Entrez ID: 1659

Protein name: ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX8 in