DegronMD

Uniprot ID: Q14562

Source protein: ATP-dependent RNA helicase DHX8

Source gene: DHX8

Class: DEG_Kelch_Keap1_1

Location: 339:344

E3 ligase: KEAP1

DEGRON score: 0.9989

ASA_SCORE: 81.1

COIL: 0.7813

CONS_SCORE: 0.3274

DSS_SCORE: 0.6234

HELIX: 0.178

FCONS_SCORE: 1.2028

RIG_SCORE: 0.7115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R352Q	TCGA-AA-3510	COAD	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.R352Q	DO7783	COAD	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.R352Q	SIDM02035	Colorectal Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.L346I	TCGA-AX-A2HC	UCEC	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.2778
p.L346I	DO41572	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2778
p.M335I	TCGA-CV-7440	HNSC	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.M335I	DO15078	HNSC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.D345E	TCGA-D1-A1NS	UCEC	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.3056
p.D345E	DO42193	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.3056
p.R351W	TCGA-DC-6683	READ	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.R351W	DO222817	BTCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.R351W	DO37018	READ	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.D339N	TCGA-DU-6392	LGG	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.5821
p.D339N	DO22237	LGG	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.5821
p.L354F	TCGA-LN-A9FP	ESCA	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.0556
p.D337Y	DO229035	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2778
p.G343V	SIDM02026	Colorectal Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25205	DNA replication licensing factor MCM3	DEG_Kelch_Keap1_1	385:390	DQETGE	KEAP1	0.8709	More...
Q14562	ATP-dependent RNA helicase DHX8	DEG_Kelch_Keap1_1	339:344	DQETGE	KEAP1	0.9989	More...
Q8TDV0	G-protein coupled receptor 151	DEG_Kelch_Keap1_1	411:416	DQETGE	KEAP1	0.7435	More...
Q96TA1	Protein Niban 2	DEG_Kelch_Keap1_1	716:721	DQETGE	KEAP1	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons