DegronMD - P25205(MCM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R183C	TCGA-AG-A002	READ	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R183H	TCGA-AX-A2HC	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R183H	DO41572	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R183H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R183H	REH	haematopoietic and lymphoid tissue	COSMIC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R188S	TCGA-BG-A222	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.2778
p.R381C	TCGA-D3-A8GB	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2222
p.R381C	TCGA-YG-AA3N	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2222
p.R381C	DO50280	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2222
p.R381C	DO51298	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2222
p.R202Q	TCGA-EO-A22R	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.R188H	TCGA-F5-6814	READ	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.2778
p.R188H	SIDM01051	Ovarian Carcinoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.2778
p.R188H	EFO-27	ovary	COSMIC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.2778
p.Q398E	TCGA-GL-8500	KIRP	TCGA	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1111
p.Q398E	DO44493	KIRP	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1111
p.C193R	TCGA-HZ-7918	PAAD	TCGA	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation altering degron motif	0.8301
p.S393F	TCGA-LH-A9QB	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.25
p.S393F	DO51266	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.25
p.V187I	DO230312	COCA	ICGC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.25
p.V187I	SIDM01612	Endometrial Carcinoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.25
p.N385K	DO227720	COCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation altering degron motif	0.6918
p.L198I	DO14766	HNSC	ICGC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation blocking phosphorylation signal	0.6944
p.A388D	DO229019	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation altering degron motif	0.7793
p.P392Q	DO229015	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2778
p.S397C	DO50758	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1389
p.S397C	DO23260	LINC	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1389
p.N397S	DO231043	LUSC	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1389
p.R395Q	DO46657	PAAD	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.1944
p.V394I	DO46873	RECA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation rewiring degron network	0.2222
p.G383C	DO50278	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation blocking phosphorylation signal	0.7222
p.R384L	DO229275	THCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation blocking phosphorylation signal	0.75
p.A390T	DO41871	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	385:390	Mutation altering degron motif	0.7139
p.G186D	DO43755	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.2222
p.A183V	DO41422	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.1389
p.P194H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation altering degron motif	0.7694
p.P194H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation altering degron motif	0.7694
p.S189N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LSVYKD	LIG_APCC_ABBA_1	190:195	Mutation rewiring degron network	0.3056

Kaplan plot for MCM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM3

UniProt ID: P25205

Entrez ID: 4172

Protein name: DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM3 in