DegronMD

Uniprot ID: P25205

Source protein: DNA replication licensing factor MCM3

Source gene: MCM3

Class: DEG_Kelch_Keap1_1

Location: 385:390

E3 ligase: KEAP1

DEGRON score: 0.8709

ASA_SCORE: 83.4667

COIL: 0.9135

CONS_SCORE: 0.7926

DSS_SCORE: 0.4474

HELIX: 0.0098

FCONS_SCORE: 0.888

RIG_SCORE: 0.7822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R381C	TCGA-D3-A8GB	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.R381C	TCGA-YG-AA3N	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.R381C	DO50280	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.R381C	DO51298	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.Q398E	TCGA-GL-8500	KIRP	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.Q398E	DO44493	KIRP	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.S393F	TCGA-LH-A9QB	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.25
p.S393F	DO51266	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.25
p.N385K	DO227720	COCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.6918
p.A388D	DO229019	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.7793
p.P392Q	DO229015	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2778
p.S397C	DO50758	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.S397C	DO23260	LINC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.N397S	DO231043	LUSC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1389
p.R395Q	DO46657	PAAD	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1944
p.V394I	DO46873	RECA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2222
p.G383C	DO50278	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.7222
p.R384L	DO229275	THCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.75
p.A390T	DO41871	UCEC	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25205	DNA replication licensing factor MCM3	DEG_Kelch_Keap1_1	385:390	DQETGE	KEAP1	0.8709	More...
Q14562	ATP-dependent RNA helicase DHX8	DEG_Kelch_Keap1_1	339:344	DQETGE	KEAP1	0.9989	More...
Q8TDV0	G-protein coupled receptor 151	DEG_Kelch_Keap1_1	411:416	DQETGE	KEAP1	0.7435	More...
Q96TA1	Protein Niban 2	DEG_Kelch_Keap1_1	716:721	DQETGE	KEAP1	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons