DegronMD

Uniprot ID: Q96TA1

Source protein: Protein Niban 2

Source gene: NIBAN2

Class: DEG_Kelch_Keap1_1

Location: 716:721

E3 ligase: KEAP1

DEGRON score: 0.9746

ASA_SCORE: 98

COIL: 0.836

CONS_SCORE: 0.3143

DSS_SCORE: 0.8703

HELIX: 0.148

FCONS_SCORE: 1.0263

RIG_SCORE: 0.5674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S715T	SIDM00987	Thyroid Gland Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.3056
p.A706S	SIDM01716	Non-Cancerous	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.0556
p.A706S	SIDM00175	Melanoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.0556
p.P714A	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	DQETGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25205	DNA replication licensing factor MCM3	DEG_Kelch_Keap1_1	385:390	DQETGE	KEAP1	0.8709	More...
Q14562	ATP-dependent RNA helicase DHX8	DEG_Kelch_Keap1_1	339:344	DQETGE	KEAP1	0.9989	More...
Q8TDV0	G-protein coupled receptor 151	DEG_Kelch_Keap1_1	411:416	DQETGE	KEAP1	0.7435	More...
Q96TA1	Protein Niban 2	DEG_Kelch_Keap1_1	716:721	DQETGE	KEAP1	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons