DegronMD

Uniprot ID: Q8TDV0

Source protein: G-protein coupled receptor 151

Source gene: GPR151

Class: DEG_Kelch_Keap1_1

Location: 411:416

E3 ligase: KEAP1

DEGRON score: 0.7435

ASA_SCORE: 99.9667

COIL: 0.8345

CONS_SCORE: 0.5969

DSS_SCORE: 0.8817

HELIX: 0.1413

FCONS_SCORE: 0.7894

RIG_SCORE: 0.6704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G415V	TCGA-D3-A3C6	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.7532
p.G415V	DO37507	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.7532
p.E416K	TCGA-FW-A3R5	SKCM	TCGA	DQETGE	DEG_Kelch_Keap1_1	0.7022
p.E416K	DO37406	SKCM	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.7022
p.V418I	DO222488	COCA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.2778
p.D403E	DO229027	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1111
p.D403E	DO229009	LICA	ICGC	DQETGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25205	DNA replication licensing factor MCM3	DEG_Kelch_Keap1_1	385:390	DQETGE	KEAP1	0.8709	More...
Q14562	ATP-dependent RNA helicase DHX8	DEG_Kelch_Keap1_1	339:344	DQETGE	KEAP1	0.9989	More...
Q8TDV0	G-protein coupled receptor 151	DEG_Kelch_Keap1_1	411:416	DQETGE	KEAP1	0.7435	More...
Q96TA1	Protein Niban 2	DEG_Kelch_Keap1_1	716:721	DQETGE	KEAP1	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons