DegronMD

Uniprot ID: P25205

Source protein: DNA replication licensing factor MCM3

Source gene: MCM3

Class: LIG_APCC_ABBA_1

Location: 190:195

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8039

ASA_SCORE: 70.5

COIL: 0.6113

CONS_SCORE: 0.6701

DSS_SCORE: 0.4362

HELIX: 0.0182

FCONS_SCORE: 0.971

RIG_SCORE: 0.7685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R183C	TCGA-AG-A002	READ	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R183H	TCGA-AX-A2HC	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R183H	DO41572	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R183H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R183H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R188S	TCGA-BG-A222	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.2778
p.R202Q	TCGA-EO-A22R	UCEC	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.R188H	TCGA-F5-6814	READ	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.2778
p.R188H	SIDM01051	Ovarian Carcinoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	0.2778
p.R188H	EFO-27	ovary	COSMIC	LSVYKD	LIG_APCC_ABBA_1	0.2778
p.C193R	TCGA-HZ-7918	PAAD	TCGA	LSVYKD	LIG_APCC_ABBA_1	0.8301
p.V187I	DO230312	COCA	ICGC	LSVYKD	LIG_APCC_ABBA_1	0.25
p.V187I	SIDM01612	Endometrial Carcinoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	0.25
p.L198I	DO14766	HNSC	ICGC	LSVYKD	LIG_APCC_ABBA_1	0.6944
p.G186D	DO43755	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	0.2222
p.A183V	DO41422	UCEC	ICGC	LSVYKD	LIG_APCC_ABBA_1	0.1389
p.P194H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSVYKD	LIG_APCC_ABBA_1	0.7694
p.P194H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSVYKD	LIG_APCC_ABBA_1	0.7694
p.S189N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LSVYKD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25205	DNA replication licensing factor MCM3	LIG_APCC_ABBA_1	190:195	LSVYKD	APC,CDC20,FZR1	0.8039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons