DegronMD

Uniprot ID: Q8N5V2

Source protein: Ephexin-1

Source gene: NGEF

Class: DEG_APCC_DBOX_1

Location: 232:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9803

ASA_SCORE: 93.2222

COIL: 0.7174

CONS_SCORE: 0.3734

DSS_SCORE: 0.6269

HELIX: 0.1979

FCONS_SCORE: 1.0888

RIG_SCORE: 0.718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L236M	TCGA-A5-A1OF	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.711
p.I239S	TCGA-BG-A221	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.7341
p.R248M	TCGA-BS-A0TJ	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.1111
p.N250S	TCGA-DA-A1I8	SKCM	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.0556
p.S229I	TCGA-DF-A2KU	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.25
p.P227L	TCGA-FI-A2D5	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.1944
p.K234N	TCGA-L4-A4E6	LUAD	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	0.5806
p.T235I	SIDM00334	Endometrial Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	0.5966
p.T235I	MFE-296	endometrium	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.5966
p.S229N	SIDM00216	Colorectal Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	0.25
p.S229N	SNU-175	large_intestine	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.25
p.R248S	SIDM00710	Small Cell Lung Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	0.1111
p.R248S	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	0.1111
p.L240I	ACH-000305	Esophageal Cancer	CCLE	ERKTLPQIC	DEG_APCC_DBOX_1	0.7174
p.L240I	EC-GI-10	oesophagus	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.7174
p.V229I	ACH-000568	Breast Cancer	CCLE	ERKTLPQIC	DEG_APCC_DBOX_1	0.25
p.V229I	UACC-812	breast	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.25
p.V232M	LNCaP-Clone-FGC	prostate	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.7208
p.A222V	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5V2	Ephexin-1	DEG_APCC_DBOX_1	232:240	ERKTLPQIC	APC,CDC20,FZR1	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons