DegronMD - Q8N5V2(NGEF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L236M	TCGA-A5-A1OF	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.711
p.I239S	TCGA-BG-A221	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.7341
p.R248M	TCGA-BS-A0TJ	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.A597T	TCGA-D1-A167	UCEC	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.7139
p.A597T	DO40978	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.7139
p.Q586K	TCGA-D3-A3C7	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.0556
p.Q586K	DO47569	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.0556
p.N250S	TCGA-DA-A1I8	SKCM	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556
p.S229I	TCGA-DF-A2KU	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.R600K	TCGA-EE-A3JA	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.6126
p.R600K	DO47625	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.6126
p.C614Y	TCGA-FI-A2D5	UCEC	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.1389
p.C614Y	DO41331	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.1389
p.P227L	TCGA-FI-A2D5	UCEC	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.R600S	TCGA-FS-A1Z4	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.6316
p.R600S	DO37462	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.6316
p.P598T	TCGA-FS-A1ZP	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.7031
p.P598T	DO37703	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.7031
p.K234N	TCGA-L4-A4E6	LUAD	TCGA	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.5806
p.Q587H	DO48998	CESC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation blocking phosphorylation signal	0.5278
p.R609H	DO10373	COAD	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.2778
p.R609H	DO227987	COCA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.2778
p.R609H	DO41903	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.2778
p.S614R	DO228976	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.1389
p.N606K	DO229019	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.6918
p.T594A	DO229022	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation blocking phosphorylation signal	0.7222
p.S586Y	DO28249	OV	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.0556
p.R615Q	DO35116	PACA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.1111
p.Q605P	DO47052	RECA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation altering degron motif	0.7035
p.E591K	DO229453	SKCA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	596:607	Mutation rewiring degron network	0.1944
p.T235I	SIDM00334	Endometrial Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.5966
p.T235I	MFE-296	endometrium	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.5966
p.S229N	SIDM00216	Colorectal Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.S229N	SNU-175	large intestine	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.R248S	SIDM00710	Small Cell Lung Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.R248S	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.L240I	ACH-000305	Esophageal Cancer	CCLE	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.7174
p.L240I	EC-GI-10	oesophagus	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.7174
p.V229I	ACH-000568	Breast Cancer	CCLE	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.V229I	UACC-812	breast	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.V232M	LNCaP-Clone-FGC	prostate	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.7208
p.A222V	SKM-1	haematopoietic and lymphoid tissue	COSMIC	ERKTLPQIC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556

Kaplan plot for NGEF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NGEF

UniProt ID: Q8N5V2

Entrez ID: 25791

Protein name: Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NGEF in