DegronMD

Uniprot ID: Q8N5V2

Source protein: Ephexin-1

Source gene: NGEF

Class: DEG_ODPH_VHL_1

Location: 596:607

E3 ligase: VHL

DEGRON score: 0.7891

ASA_SCORE: 85.5083

COIL: 0.7173

CONS_SCORE: 0.3953

DSS_SCORE: 0.2778

HELIX: 0.2093

FCONS_SCORE: 0.8599

RIG_SCORE: 0.7826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A597T	TCGA-D1-A167	UCEC	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7139
p.A597T	DO40978	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7139
p.Q586K	TCGA-D3-A3C7	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.0556
p.Q586K	DO47569	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.0556
p.R600K	TCGA-EE-A3JA	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.6126
p.R600K	DO47625	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.6126
p.C614Y	TCGA-FI-A2D5	UCEC	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.1389
p.C614Y	DO41331	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.1389
p.R600S	TCGA-FS-A1Z4	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.6316
p.R600S	DO37462	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.6316
p.P598T	TCGA-FS-A1ZP	SKCM	TCGA	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7031
p.P598T	DO37703	SKCM	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7031
p.Q587H	DO48998	CESC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.5278
p.R609H	DO10373	COAD	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.2778
p.R609H	DO227987	COCA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.2778
p.R609H	DO41903	UCEC	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.2778
p.S614R	DO228976	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.1389
p.N606K	DO229019	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.6918
p.T594A	DO229022	LICA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7222
p.S586Y	DO28249	OV	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.0556
p.R615Q	DO35116	PACA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.1111
p.Q605P	DO47052	RECA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.7035
p.E591K	DO229453	SKCA	ICGC	LAPNRRTKFVSF	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5V2	Ephexin-1	DEG_ODPH_VHL_1	596:607	LAPNRRTKFVSF	VHL	0.7891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons