DegronMD

Uniprot ID: O75146

Source protein: Huntingtin-interacting protein 1-related protein

Source gene: HIP1R

Class: DEG_APCC_DBOX_1

Location: 997:1005

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5812

ASA_SCORE: 88.6889

COIL: 0.0403

CONS_SCORE: 0.6038

DSS_SCORE: 0.3139

HELIX: 0.9611

FCONS_SCORE: 1.1732

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1005Q	TCGA-ZG-A9LY	PRAD	TCGA	ERMRLGELR	DEG_APCC_DBOX_1	0.6218
p.R1005Q	DO219438	PRAD	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	0.6218
p.A996S	DO229019	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	0.3056
p.A1014S	DO229032	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	0.0833
p.R1000L	DO229035	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	0.7316
p.G1002W	DO229045	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	0.6714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75146	Huntingtin-interacting protein 1-related protein	DEG_APCC_DBOX_1	997:1005	ERMRLGELR	APC,CDC20,FZR1	0.5812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons