DegronMD - O75146(HIP1R)

HIP1R

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R413H	TCGA-BG-A0M4	UCEC	TCGA	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.8244
p.R413H	DO41686	UCEC	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.8244
p.R1005Q	TCGA-ZG-A9LY	PRAD	TCGA	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6218
p.R1005Q	DO219438	PRAD	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6218
p.K402M	DO228278	LICA	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation substituting flanking lysine	0.1667
p.A996S	DO229019	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.3056
p.A1014S	DO229032	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.0833
p.A417S	DO229036	LICA	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6477
p.R1000L	DO229035	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.7316
p.G1002W	DO229045	LICA	ICGC	ERMRLGELR	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6714
p.E415K	SIDM00792	Small Cell Lung Carcinoma	GDSC	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.591
p.E415K	ACH-002170	Lung Cancer	CCLE	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.591
p.E415K	NCI-H1688	lung	COSMIC	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.591
p.R413C	ACH-000104	Leukemia	CCLE	LRHELAQLR	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.8301

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*NOTE: the Kaplan plots were collected from OncoLnc