DegronMD

Uniprot ID: O75146

Source protein: Huntingtin-interacting protein 1-related protein

Source gene: HIP1R

Class: DEG_APCC_DBOX_1

Location: 412:420

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8803

ASA_SCORE: 98.1667

COIL: 0.0151

CONS_SCORE: 0.4655

DSS_SCORE: 0.4463

HELIX: 0.9847

FCONS_SCORE: 1.2437

RIG_SCORE: 0.7858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R413H	TCGA-BG-A0M4	UCEC	TCGA	LRHELAQLR	DEG_APCC_DBOX_1	0.8244
p.R413H	DO41686	UCEC	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	0.8244
p.K402M	DO228278	LICA	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	0.1667
p.A417S	DO229036	LICA	ICGC	LRHELAQLR	DEG_APCC_DBOX_1	0.6477
p.E415K	SIDM00792	Small Cell Lung Carcinoma	GDSC	LRHELAQLR	DEG_APCC_DBOX_1	0.591
p.E415K	ACH-002170	Lung Cancer	CCLE	LRHELAQLR	DEG_APCC_DBOX_1	0.591
p.E415K	NCI-H1688	lung	COSMIC	LRHELAQLR	DEG_APCC_DBOX_1	0.591
p.R413C	ACH-000104	Leukemia	CCLE	LRHELAQLR	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75146	Huntingtin-interacting protein 1-related protein	DEG_APCC_DBOX_1	412:420	LRHELAQLR	APC,CDC20,FZR1	0.8803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons