DegronMD

Uniprot ID: Q14839

Source protein: Chromodomain-helicase-DNA-binding protein 4

Source gene: CHD4

Class: DEG_APCC_DBOX_1

Location: 1889:1897

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.851

ASA_SCORE: 60.6333

COIL: 0.0734

CONS_SCORE: 0.2798

DSS_SCORE: 0.4771

HELIX: 0.9239

FCONS_SCORE: 1.0704

RIG_SCORE: 0.7526

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1903S	TCGA-A5-A0G2	UCEC	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	0.1667
p.P1879A	TCGA-AA-3815	COAD	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	0.0556
p.E1902K	TCGA-BH-A1FE	BRCA	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	0.1944
p.A1882V	TCGA-CK-6746	COAD	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	0.1389
p.P1879S	TCGA-FR-A8YC	SKCM	TCGA	ERNILSRLA	DEG_APCC_DBOX_1	0.0556
p.E1895K	DO4830	BRCA	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	0.7022
p.Q1904K	DO229006	LICA	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	0.5833
p.N1884D	DO38404	STAD	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	0.1944
p.P1896S	DO41235	UCEC	ICGC	ERNILSRLA	DEG_APCC_DBOX_1	0.6752
p.S1894T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	0.6005
p.S1894T	ACH-000809	Esophageal Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	0.6005
p.S1894T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.6005
p.Q1886H	SIDM00683	Prostate Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.Q1886H	ACH-000977	lymph_node	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.Q1886H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.R1895L	SIDM00476	Ovarian Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	0.7316
p.R1895L	ACH-001373	Ovarian Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	0.7316
p.R1895L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7316
p.A1900T	SIDM00217	Colorectal Carcinoma	GDSC	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.A1900T	ACH-000999	Colon/Colorectal Cancer	CCLE	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.A1900T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.A1891T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7139
p.R1897L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.8428
p.S1896T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7116
p.A1887T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.2778
p.S1902T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1944
p.R1888L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.75
p.R1882L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1389
p.A1902T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1944
p.R1903L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1667
p.Q1888H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.75
p.Q1879H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.0556
p.R1886L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.25
p.R1885L	OV-17R	ovary	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.2222
p.A1890T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7139
p.S1884T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1944
p.A1880T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.0833
p.S1887T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.2778
p.Q1894H	LNCaP-Clone-FGC	prostate	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7582
p.S1885T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.2222
p.A1893T	SNU-1040	large_intestine	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.7139
p.S1881T	KYSE-410	oesophagus	COSMIC	ERNILSRLA	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERNILSRLA

Degron related mutations and impact score

Drug responses associated with CHD4 mutations

All proteins holding degron of ERNILSRLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14839	Chromodomain-helicase-DNA-binding protein 4	DEG_APCC_DBOX_1	1889:1897	ERNILSRLA	APC,CDC20,FZR1	0.851	More...