DegronMD

Uniprot ID: O95393

Source protein: Bone morphogenetic protein 10

Source gene: BMP10

Class: DEG_APCC_DBOX_1

Location: 180:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5113

ASA_SCORE: 52.8667

COIL: 0.1543

CONS_SCORE: 0.4639

DSS_SCORE: 0.3158

HELIX: 0.01

FCONS_SCORE: 1.0722

RIG_SCORE: 0.8555

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L184M	TCGA-05-4427	LUAD	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.711
p.L184M	DO23666	LUAD	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.711
p.E172D	TCGA-06-5416	GBM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.1111
p.E172D	DO10880	GBM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1111
p.K174N	TCGA-24-1427	OV	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.2778
p.K174N	DO28471	OV	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.2778
p.S188Y	TCGA-CA-6717	COAD	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.6009
p.S188Y	DO8264	COAD	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.6009
p.R181I	TCGA-D1-A16Y	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.8102
p.R181I	DO41524	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.8102
p.G175V	TCGA-D1-A2G0	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G175V	DO43049	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	TCGA-EB-A3Y7	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	TCGA-EE-A2MD	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	TCGA-ER-A193	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	DO222434	MELA	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	DO37851	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	DO37499	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.G193R	DO47368	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1944
p.I191V	TCGA-EY-A1GS	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.25
p.I191V	DO43162	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.25
p.G179E	TCGA-Z2-A8RT	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	0.3056
p.G179E	DO51301	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.3056
p.S188F	DO220912	MELA	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	0.6871
p.N195T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1389
p.N195T	ACH-002256	Leukemia	CCLE	ERNMLVLVS	DEG_APCC_DBOX_1	0.1389
p.N195T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ERNMLVLVS	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95393	Bone morphogenetic protein 10	DEG_APCC_DBOX_1	180:188	ERNMLVLVS	APC,CDC20,FZR1	0.5113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERNMLVLVS

Degron related mutations and impact score

Drug responses associated with BMP10 mutations

All proteins holding degron of ERNMLVLVS