DegronMD - O95393(BMP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L184M	TCGA-05-4427	LUAD	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.711
p.L184M	DO23666	LUAD	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.711
p.E172D	TCGA-06-5416	GBM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1111
p.E172D	DO10880	GBM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1111
p.K174N	TCGA-24-1427	OV	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation substituting flanking lysine	0.2778
p.K174N	DO28471	OV	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation substituting flanking lysine	0.2778
p.S235C	TCGA-AD-6901	COAD	TCGA	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.S235C	DO9218	COAD	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.E232D	TCGA-BF-A1PZ	SKCM	TCGA	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1389
p.E232D	DO50279	SKCM	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1389
p.S188Y	TCGA-CA-6717	COAD	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.6009
p.S188Y	DO8264	COAD	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.6009
p.R181I	TCGA-D1-A16Y	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.8102
p.R181I	DO41524	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.8102
p.G175V	TCGA-D1-A2G0	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G175V	DO43049	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.E268K	TCGA-D9-A6EC	SKCM	TCGA	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.0556
p.E268K	DO50291	SKCM	ICGC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.0556
p.G193R	TCGA-EB-A3Y7	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	TCGA-EE-A2MD	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	TCGA-ER-A193	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	DO222434	MELA	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	DO37851	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	DO37499	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.G193R	DO47368	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.I191V	TCGA-EY-A1GS	UCEC	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.25
p.I191V	DO43162	UCEC	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.25
p.D233N	TCGA-YD-A89C	SKCM	TCGA	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.D233N	DO219501	SKCM	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1111
p.G179E	TCGA-Z2-A8RT	SKCM	TCGA	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.3056
p.G179E	DO51301	SKCM	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.3056
p.D229E	DO228531	LICA	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.2222
p.Q211K	DO228952	LICA	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.S188F	DO220912	MELA	ICGC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.6871
p.H223Y	DO222647	MELA	ICGC	LEVHIE	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.6118
p.H249Q	DO46897	RECA	ICGC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.2222
p.N250K	SIDM00855	Other Sarcomas	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.25
p.N250K	SIDM01112	Osteosarcoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.25
p.N250K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.25
p.N250K	SIDM00844	Burkitt's Lymphoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.25
p.N250K	SIDM01147	Gastric Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.25
p.Q246H	SIDM00789	Colorectal Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.Q246H	ACH-000997	Colon/Colorectal Cancer	CCLE	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.Q246H	HCT-15	large intestine	COSMIC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation rewiring degron network	0.1389
p.N195T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.N195T	ACH-002256	Leukemia	CCLE	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.N195T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ERNMLVLVS	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.V255M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.6097
p.V255M	ACH-000953	Leukemia	CCLE	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.6097
p.V255M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.6097
p.L253V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.5654
p.L253V	ACH-000937	Leukemia	CCLE	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.5654
p.L253V	PF-382	haematopoietic and lymphoid tissue	COSMIC	LIVFSD	LIG_APCC_ABBA_1	253:258	Mutation altering degron motif	0.5654

Kaplan plot for BMP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMP10

UniProt ID: O95393

Entrez ID: 27302

Protein name: Bone morphogenetic protein 10 (BMP-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMP10 in