DegronMD

Uniprot ID: O95393

Source protein: Bone morphogenetic protein 10

Source gene: BMP10

Class: LIG_APCC_ABBA_1

Location: 253:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8564

ASA_SCORE: 17.6833

COIL: 0.1558

CONS_SCORE: 0.6469

DSS_SCORE: 0.6003

HELIX: 0.0077

FCONS_SCORE: 1.4117

RIG_SCORE: 0.7621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E268K	TCGA-D9-A6EC	SKCM	TCGA	LIVFSD	LIG_APCC_ABBA_1	0.0556
p.E268K	DO50291	SKCM	ICGC	LIVFSD	LIG_APCC_ABBA_1	0.0556
p.H249Q	DO46897	RECA	ICGC	LIVFSD	LIG_APCC_ABBA_1	0.2222
p.N250K	SIDM00855	Other Sarcomas	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.25
p.N250K	SIDM01112	Osteosarcoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.25
p.N250K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.25
p.N250K	SIDM00844	Burkitt's Lymphoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.25
p.N250K	SIDM01147	Gastric Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.25
p.Q246H	SIDM00789	Colorectal Carcinoma	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.1389
p.Q246H	ACH-000997	Colon/Colorectal Cancer	CCLE	LIVFSD	LIG_APCC_ABBA_1	0.1389
p.Q246H	HCT-15	large_intestine	COSMIC	LIVFSD	LIG_APCC_ABBA_1	0.1389
p.V255M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.6097
p.V255M	ACH-000953	Leukemia	CCLE	LIVFSD	LIG_APCC_ABBA_1	0.6097
p.V255M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LIVFSD	LIG_APCC_ABBA_1	0.6097
p.L253V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LIVFSD	LIG_APCC_ABBA_1	0.5654
p.L253V	ACH-000937	Leukemia	CCLE	LIVFSD	LIG_APCC_ABBA_1	0.5654
p.L253V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LIVFSD	LIG_APCC_ABBA_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95393	Bone morphogenetic protein 10	LIG_APCC_ABBA_1	253:258	LIVFSD	APC,CDC20,FZR1	0.8564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons