DegronMD

Uniprot ID: O95393

Source protein: Bone morphogenetic protein 10

Source gene: BMP10

Class: LIG_APCC_ABBA_1

Location: 220:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8556

ASA_SCORE: 20.4

COIL: 0.0202

CONS_SCORE: 0.5899

DSS_SCORE: 0.5853

HELIX: 0.0088

FCONS_SCORE: 1.3055

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S235C	TCGA-AD-6901	COAD	TCGA	LEVHIE	LIG_APCC_ABBA_1	0.0556
p.S235C	DO9218	COAD	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.0556
p.E232D	TCGA-BF-A1PZ	SKCM	TCGA	LEVHIE	LIG_APCC_ABBA_1	0.1389
p.E232D	DO50279	SKCM	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.1389
p.D233N	TCGA-YD-A89C	SKCM	TCGA	LEVHIE	LIG_APCC_ABBA_1	0.1111
p.D233N	DO219501	SKCM	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.1111
p.D229E	DO228531	LICA	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.2222
p.Q211K	DO228952	LICA	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.0833
p.H223Y	DO222647	MELA	ICGC	LEVHIE	LIG_APCC_ABBA_1	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95393	Bone morphogenetic protein 10	LIG_APCC_ABBA_1	220:225	LEVHIE	APC,CDC20,FZR1	0.8556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons