DegronMD

Uniprot ID: Q15436

Source protein: Protein transport protein Sec23A

Source gene: SEC23A

Class: DEG_APCC_DBOX_1

Location: 47:55

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6985

ASA_SCORE: 93.0556

COIL: 0.923

CONS_SCORE: 0.4275

DSS_SCORE: 0.1977

HELIX: 0.0229

FCONS_SCORE: 0.7062

RIG_SCORE: 0.768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P37S	TCGA-44-A47B	LUAD	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.P37S	DO45353	LUAD	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.P37H	TCGA-A5-A1OF	UCEC	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.P37H	DO42568	UCEC	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.A40S	TCGA-DU-6392	LGG	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1389
p.A40S	DO22237	LGG	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1389
p.R63M	TCGA-EE-A29X	SKCM	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1111
p.R63M	DO37595	SKCM	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1111
p.L45P	TCGA-F1-6177	STAD	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.2778
p.L45P	DO38727	STAD	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.2778
p.R63S	TCGA-FS-A1ZR	SKCM	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1111
p.R63S	DO37651	SKCM	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1111
p.D50N	TCGA-SY-A9G5	BLCA	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	0.5821
p.D50N	DO51906	BLCA	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.5821
p.P53T	DO229027	LICA	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.5919
p.P44L	DO52650	MALY	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.25
p.P44A	SIDM01148	Plasma Cell Myeloma	GDSC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.25
p.P44A	ACH-000050	Myeloma	CCLE	ERPDLPPIQ	DEG_APCC_DBOX_1	0.25
p.P44A	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.25
p.P37L	SIDM00865	Small Cell Lung Carcinoma	GDSC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.P37L	ACH-000530	Lung Cancer	CCLE	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.P37L	DMS-114	lung	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.0556
p.S61F	SW684	soft_tissue	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15436	Protein transport protein Sec23A	DEG_APCC_DBOX_1	47:55	ERPDLPPIQ	APC,CDC20,FZR1	0.6985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons