DegronMD - Q15436(SEC23A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R716C	TCGA-17-Z053	LUAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation altering degron motif	0.8301
p.S452G	TCGA-37-A5EM	LUSC	TCGA	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.1944
p.P37S	TCGA-44-A47B	LUAD	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.P37S	DO45353	LUAD	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.G711E	TCGA-A5-A0G2	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation rewiring degron network	0.2222
p.D319G	TCGA-A5-A0G2	UCEC	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.1389
p.P37H	TCGA-A5-A1OF	UCEC	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.P37H	DO42568	UCEC	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.D304Y	TCGA-AJ-A3EK	UCEC	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.2778
p.S713G	TCGA-AX-A06F	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation blocking phosphorylation signal	0.7222
p.K318N	TCGA-AZ-4315	COAD	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation substituting flanking lysine	0.2778
p.S713N	TCGA-BR-8059	STAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation blocking phosphorylation signal	0.7222
p.P298L	TCGA-C8-A12T	BRCA	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.1111
p.R716H	TCGA-CK-4951	COAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation altering degron motif	0.8244
p.R716H	TCGA-E6-A2P8	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation altering degron motif	0.8244
p.T708I	TCGA-CV-7434	HNSC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation rewiring degron network	0.1389
p.R716S	TCGA-D3-A2J6	SKCM	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation altering degron motif	0.7427
p.M731I	TCGA-DI-A1BU	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation rewiring degron network	0.1111
p.A40S	TCGA-DU-6392	LGG	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1389
p.A40S	DO22237	LGG	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1389
p.R63M	TCGA-EE-A29X	SKCM	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.R63M	DO37595	SKCM	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.S312L	TCGA-EI-6882	READ	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation altering degron motif	0.7667
p.S312L	SIDM01962	Colorectal Carcinoma	GDSC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation altering degron motif	0.7667
p.L45P	TCGA-F1-6177	STAD	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2778
p.L45P	DO38727	STAD	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2778
p.R63S	TCGA-FS-A1ZR	SKCM	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.R63S	DO37651	SKCM	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.D319E	TCGA-HQ-A2OE	BLCA	TCGA	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.1389
p.D50N	TCGA-SY-A9G5	BLCA	TCGA	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5821
p.D50N	DO51906	BLCA	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5821
p.C318S	DO5284	BRCA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation substituting flanking lysine	0.2778
p.A463V	DO50092	COAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.3056
p.L300R	DO222576	COCA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.1667
p.K303E	DO234168	ESAD	ICGC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.25
p.P305R	DO233732	GACA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.3056
p.E469Q	DO20770	KIRP	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.1389
p.P53T	DO229027	LICA	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5919
p.T314K	DO229026	LICA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.2778
p.H458D	DO45217	LIRI	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation altering degron motif	0.7688
p.A471S	DO45143	LIRI	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.0833
p.Q471H	DO26650	LUSC	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.0833
p.P44L	DO52650	MALY	ICGC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.25
p.S449F	DO220907	MELA	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation blocking ubiquitination signal	0.5556
p.R466Q	DO46657	PAAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.2222
p.F448L	DO36365	PRAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.0833
p.G469A	DO47753	STAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.1389
p.D449Y	DO229242	THCA	ICGC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation blocking ubiquitination signal	0.5556
p.A321T	SIDM00602	Gastric Carcinoma	GDSC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.0833
p.A321T	ACH-000919	Gastric Cancer	CCLE	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.0833
p.A321T	IM-95	stomach	COSMIC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.0833
p.P44A	SIDM01148	Plasma Cell Myeloma	GDSC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.25
p.P44A	ACH-000050	Myeloma	CCLE	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.25
p.P44A	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.25
p.P37L	SIDM00865	Small Cell Lung Carcinoma	GDSC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.P37L	ACH-000530	Lung Cancer	CCLE	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.P37L	DMS-114	lung	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.Y460S	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation altering degron motif	0.712
p.P309S	ACH-001347	Head and Neck Cancer	CCLE	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation altering degron motif	0.6752
p.V453A	NCI-H2196	lung	COSMIC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.2222
p.A731T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	715:723	Mutation rewiring degron network	0.1111
p.A320V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LKTPIRS	DEG_SCF_FBW7_1	306:312	Mutation rewiring degron network	0.1111
p.R464H	REH	haematopoietic and lymphoid tissue	COSMIC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.2778
p.S61F	SW684	soft tissue	COSMIC	ERPDLPPIQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1667
p.R447H	REH	haematopoietic and lymphoid tissue	COSMIC	LAIYFE	LIG_APCC_ABBA_1	457:462	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC23A

UniProt ID: Q15436

Entrez ID: 10484

Protein name: Protein transport protein Sec23A (hSec23A) (SEC23-related protein A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC23A in