DegronMD

Uniprot ID: Q15436

Source protein: Protein transport protein Sec23A

Source gene: SEC23A

Class: LIG_APCC_ABBA_1

Location: 457:462

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5954

ASA_SCORE: 24.8667

COIL: 0.0408

CONS_SCORE: 0.6115

DSS_SCORE: 0.1437

HELIX: 0.0073

FCONS_SCORE: 1.2727

RIG_SCORE: 0.9563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S452G	TCGA-37-A5EM	LUSC	TCGA	LAIYFE	LIG_APCC_ABBA_1	0.1944
p.A463V	DO50092	COAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.3056
p.E469Q	DO20770	KIRP	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.1389
p.H458D	DO45217	LIRI	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.7688
p.A471S	DO45143	LIRI	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.0833
p.Q471H	DO26650	LUSC	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.0833
p.S449F	DO220907	MELA	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.5556
p.R466Q	DO46657	PAAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.2222
p.F448L	DO36365	PRAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.0833
p.G469A	DO47753	STAD	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.1389
p.D449Y	DO229242	THCA	ICGC	LAIYFE	LIG_APCC_ABBA_1	0.5556
p.Y460S	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAIYFE	LIG_APCC_ABBA_1	0.712
p.V453A	NCI-H2196	lung	COSMIC	LAIYFE	LIG_APCC_ABBA_1	0.2222
p.R464H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LAIYFE	LIG_APCC_ABBA_1	0.2778
p.R447H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LAIYFE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15436	Protein transport protein Sec23A	LIG_APCC_ABBA_1	457:462	LAIYFE	APC,CDC20,FZR1	0.5954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons