DegronMD

Uniprot ID: Q15436

Source protein: Protein transport protein Sec23A

Source gene: SEC23A

Class: DEG_APCC_DBOX_1

Location: 715:723

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7446

ASA_SCORE: 29.1778

COIL: 0.243

CONS_SCORE: 0.7714

DSS_SCORE: 0.4861

HELIX: 0.0261

FCONS_SCORE: 1.3731

RIG_SCORE: 0.7569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R716C	TCGA-17-Z053	LUAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.8301
p.G711E	TCGA-A5-A0G2	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.2222
p.S713G	TCGA-AX-A06F	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.7222
p.S713N	TCGA-BR-8059	STAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.7222
p.R716H	TCGA-CK-4951	COAD	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.8244
p.R716H	TCGA-E6-A2P8	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.8244
p.T708I	TCGA-CV-7434	HNSC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.1389
p.R716S	TCGA-D3-A2J6	SKCM	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.7427
p.M731I	TCGA-DI-A1BU	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.1111
p.A731T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15436	Protein transport protein Sec23A	DEG_APCC_DBOX_1	715:723	ARFLLSKVN	APC,CDC20,FZR1	0.7446	More...
Q15437	Protein transport protein Sec23B	DEG_APCC_DBOX_1	717:725	ARFLLSKVN	APC,CDC20,FZR1	0.8854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons