DegronMD - Q15437(SEC23B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R718Q	TCGA-AP-A1DV	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.7329
p.R718Q	DO43186	UCEC	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.7329
p.L42F	TCGA-BF-A5EO	SKCM	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1944
p.L42F	DO219450	SKCM	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1944
p.E47G	TCGA-CC-A7IH	LIHC	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6087
p.E47G	DO52181	LIHC	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6087
p.P52L	TCGA-D3-A8GO	SKCM	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6471
p.P52L	DO51242	SKCM	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6471
p.A39V	TCGA-EO-A3KX	UCEC	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.A39V	DO219774	UCEC	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1111
p.E711K	TCGA-GV-A3JZ	BLCA	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1667
p.E711K	DO773	BLCA	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1667
p.T710M	TCGA-R6-A8W8	ESCA	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1389
p.R48H	DO10172	COAD	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.8244
p.R48H	SIDM01619	Endometrial Carcinoma	GDSC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.8244
p.R48H	ACH-000984	Endometrial/Uterine Cancer	CCLE	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.8244
p.R718L	DO229025	LICA	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation altering degron motif	0.8428
p.V54L	DO229041	LICA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5654
p.V59L	DO44858	LICA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.P37L	DO229502	SKCA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.P64S	SIDM01145	Gastric Carcinoma	GDSC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.P64S	ACH-000581	Gastric Cancer	CCLE	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.P64S	NCI-SNU-16	stomach	COSMIC	ERPDLPPVQ	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.I708V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.I708V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.I708V	SIDM01573	Plasma Cell Myeloma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.I708V	SIDM00016	Neuroblastoma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.I708V	RERF-LC-KJ	lung	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.I708V	HAL-01	haematopoietic and lymphoid tissue	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833

Kaplan plot for SEC23B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC23B

UniProt ID: Q15437

Entrez ID: 10483

Protein name: Protein transport protein Sec23B (hSec23B) (SEC23-related protein B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC23B in