DegronMD

Uniprot ID: Q15437

Source protein: Protein transport protein Sec23B

Source gene: SEC23B

Class: DEG_APCC_DBOX_1

Location: 47:55

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5738

ASA_SCORE: 93.9667

COIL: 0.914

CONS_SCORE: 0.4176

DSS_SCORE: 0.1936

HELIX: 0.0262

FCONS_SCORE: 0.6895

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L42F	TCGA-BF-A5EO	SKCM	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	0.1944
p.L42F	DO219450	SKCM	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.1944
p.E47G	TCGA-CC-A7IH	LIHC	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	0.6087
p.E47G	DO52181	LIHC	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.6087
p.P52L	TCGA-D3-A8GO	SKCM	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	0.6471
p.P52L	DO51242	SKCM	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.6471
p.A39V	TCGA-EO-A3KX	UCEC	TCGA	ERPDLPPVQ	DEG_APCC_DBOX_1	0.1111
p.A39V	DO219774	UCEC	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.1111
p.R48H	DO10172	COAD	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.8244
p.R48H	SIDM01619	Endometrial Carcinoma	GDSC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.8244
p.R48H	ACH-000984	Endometrial/Uterine Cancer	CCLE	ERPDLPPVQ	DEG_APCC_DBOX_1	0.8244
p.V54L	DO229041	LICA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.5654
p.V59L	DO44858	LICA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.2222
p.P37L	DO229502	SKCA	ICGC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.0556
p.P64S	SIDM01145	Gastric Carcinoma	GDSC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.0833
p.P64S	ACH-000581	Gastric Cancer	CCLE	ERPDLPPVQ	DEG_APCC_DBOX_1	0.0833
p.P64S	NCI-SNU-16	stomach	COSMIC	ERPDLPPVQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15437	Protein transport protein Sec23B	DEG_APCC_DBOX_1	47:55	ERPDLPPVQ	APC,CDC20,FZR1	0.5738	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons