DegronMD

Uniprot ID: Q15437

Source protein: Protein transport protein Sec23B

Source gene: SEC23B

Class: DEG_APCC_DBOX_1

Location: 717:725

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8854

ASA_SCORE: 29.1333

COIL: 0.2387

CONS_SCORE: 0.7688

DSS_SCORE: 0.4465

HELIX: 0.0082

FCONS_SCORE: 1.3761

RIG_SCORE: 0.7602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R718Q	TCGA-AP-A1DV	UCEC	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.7329
p.R718Q	DO43186	UCEC	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	0.7329
p.E711K	TCGA-GV-A3JZ	BLCA	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.1667
p.E711K	DO773	BLCA	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	0.1667
p.T710M	TCGA-R6-A8W8	ESCA	TCGA	ARFLLSKVN	DEG_APCC_DBOX_1	0.1389
p.R718L	DO229025	LICA	ICGC	ARFLLSKVN	DEG_APCC_DBOX_1	0.8428
p.I708V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833
p.I708V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833
p.I708V	SIDM01573	Plasma Cell Myeloma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833
p.I708V	SIDM00016	Neuroblastoma	GDSC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833
p.I708V	RERF-LC-KJ	lung	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833
p.I708V	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	ARFLLSKVN	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15436	Protein transport protein Sec23A	DEG_APCC_DBOX_1	715:723	ARFLLSKVN	APC,CDC20,FZR1	0.7446	More...
Q15437	Protein transport protein Sec23B	DEG_APCC_DBOX_1	717:725	ARFLLSKVN	APC,CDC20,FZR1	0.8854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons