DegronMD

Uniprot ID: Q15436

Source protein: Protein transport protein Sec23A

Source gene: SEC23A

Class: DEG_SCF_FBW7_1

Location: 306:312

E3 ligase: FBXW7

DEGRON score: 0.9604

ASA_SCORE: 67.8714

COIL: 0.807

CONS_SCORE: 0.5769

DSS_SCORE: 0.3997

HELIX: 0.1189

FCONS_SCORE: 0.9626

RIG_SCORE: 0.7938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D319G	TCGA-A5-A0G2	UCEC	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.1389
p.D304Y	TCGA-AJ-A3EK	UCEC	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.2778
p.K318N	TCGA-AZ-4315	COAD	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.2778
p.P298L	TCGA-C8-A12T	BRCA	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.1111
p.S312L	TCGA-EI-6882	READ	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.7667
p.S312L	SIDM01962	Colorectal Carcinoma	GDSC	LKTPIRS	DEG_SCF_FBW7_1	0.7667
p.D319E	TCGA-HQ-A2OE	BLCA	TCGA	LKTPIRS	DEG_SCF_FBW7_1	0.1389
p.C318S	DO5284	BRCA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	0.2778
p.L300R	DO222576	COCA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	0.1667
p.K303E	DO234168	ESAD	ICGC	LKTPIRS	DEG_SCF_FBW7_1	0.25
p.P305R	DO233732	GACA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	0.3056
p.T314K	DO229026	LICA	ICGC	LKTPIRS	DEG_SCF_FBW7_1	0.2778
p.A321T	SIDM00602	Gastric Carcinoma	GDSC	LKTPIRS	DEG_SCF_FBW7_1	0.0833
p.A321T	ACH-000919	Gastric Cancer	CCLE	LKTPIRS	DEG_SCF_FBW7_1	0.0833
p.A321T	IM-95	stomach	COSMIC	LKTPIRS	DEG_SCF_FBW7_1	0.0833
p.P309S	ACH-001347	Head and Neck Cancer	CCLE	LKTPIRS	DEG_SCF_FBW7_1	0.6752
p.A320V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LKTPIRS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15436	Protein transport protein Sec23A	DEG_SCF_FBW7_1	306:312	LKTPIRS	FBXW7	0.9604	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons