DegronMD

Uniprot ID: Q9P1V8

Source protein: Sterile alpha motif domain-containing protein 15

Source gene: SAMD15

Class: DEG_APCC_DBOX_1

Location: 21:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6645

ASA_SCORE: 104.4778

COIL: 0.9462

CONS_SCORE: 0.377

DSS_SCORE: 0.7467

HELIX: 0.0314

FCONS_SCORE: 0.9112

RIG_SCORE: 0.6495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R22K	TCGA-2W-A8YY	CESC	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	0.7237
p.R22K	DO223732	CESC	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.7237
p.Y32H	TCGA-85-8353	LUSC	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.Y32H	DO45530	LUSC	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.Y32C	TCGA-AZ-4315	COAD	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.Y32C	DO8842	COAD	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.H29Y	TCGA-CU-A3KJ	BLCA	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	0.6118
p.H29Y	DO663	BLCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.6118
p.L18P	DO229010	COCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.L18P	DO229003	COCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	0.25
p.K30E	SIDM00480	Ovarian Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	0.3056
p.K30E	ACH-000704	Ovarian Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	0.3056
p.K30E	OAW-42	ovary	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	0.3056
p.E21Q	SIDM00589	Oral Cavity Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	0.5633
p.E21Q	ACH-000778	Head and Neck Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	0.5633
p.E21Q	HSC-3	upper_aerodigestive_tract	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	0.5633
p.K30T	SIDM01588	Endometrial Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	0.3056
p.K30T	ACH-000993	Endometrial/Uterine Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	0.3056
p.S32R	EN	endometrium	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1V8	Sterile alpha motif domain-containing protein 15	DEG_APCC_DBOX_1	21:29	ERPELPGLH	APC,CDC20,FZR1	0.6645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons