DegronMD - Q9P1V8(SAMD15)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D229Y	TCGA-06-5416	GBM	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.0833
p.D229Y	DO10880	GBM	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.0833
p.D314N	TCGA-21-5787	LUSC	TCGA	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.1667
p.D314N	DO26605	LUSC	ICGC	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.1667
p.R22K	TCGA-2W-A8YY	CESC	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.7237
p.R22K	DO223732	CESC	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.7237
p.E243K	TCGA-55-7727	LUAD	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.591
p.E243K	DO24297	LUAD	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.591
p.Y32H	TCGA-85-8353	LUSC	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.Y32H	DO45530	LUSC	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.L230P	TCGA-AJ-A3EK	UCEC	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1111
p.L230P	DO41584	UCEC	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1111
p.Y32C	TCGA-AZ-4315	COAD	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.Y32C	DO8842	COAD	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.E323Q	TCGA-B5-A11R	UCEC	TCGA	STDENVPEP	DEG_COP1_1	320:328	Mutation altering degron motif	0.5633
p.E323Q	DO43787	UCEC	ICGC	STDENVPEP	DEG_COP1_1	320:328	Mutation altering degron motif	0.5633
p.K237R	TCGA-B6-A0RM	BRCA	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.3056
p.K237R	DO3128	BRCA	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.3056
p.H29Y	TCGA-CU-A3KJ	BLCA	TCGA	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.6118
p.H29Y	DO663	BLCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.6118
p.P241Q	TCGA-D3-A2JP	SKCM	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.7035
p.P241Q	DO47407	SKCM	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.7035
p.T321A	TCGA-D8-A1XK	BRCA	TCGA	STDENVPEP	DEG_COP1_1	320:328	Mutation altering degron motif	0.6028
p.T321A	DO4749	BRCA	ICGC	STDENVPEP	DEG_COP1_1	320:328	Mutation altering degron motif	0.6028
p.R318I	TCGA-EO-A22X	UCEC	TCGA	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.2778
p.R318I	DO43907	UCEC	ICGC	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.2778
p.L230I	TCGA-EO-A3B0	UCEC	TCGA	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1111
p.L230I	DO219773	UCEC	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1111
p.E331D	DO1129	BRCA	ICGC	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.25
p.L18P	DO229010	COCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.L18P	DO229003	COCA	ICGC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25
p.R253K	DO222743	MELA	ICGC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.0833
p.K30E	SIDM00480	Ovarian Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.3056
p.K30E	ACH-000704	Ovarian Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.3056
p.K30E	OAW-42	ovary	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.3056
p.E21Q	SIDM00589	Oral Cavity Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.5633
p.E21Q	ACH-000778	Head and Neck Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.5633
p.E21Q	HSC-3	upper aerodigestive tract	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation altering degron motif	0.5633
p.E242D	SIDM00282	Colorectal Carcinoma	GDSC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5647
p.E242D	ACH-000998	Colon/Colorectal Cancer	CCLE	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5647
p.E242D	CW-2	large intestine	COSMIC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5647
p.E242Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5633
p.E242Q	ACH-001638	Lymphoma	CCLE	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5633
p.E242Q	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.5633
p.K30T	SIDM01588	Endometrial Carcinoma	GDSC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.3056
p.K30T	ACH-000993	Endometrial/Uterine Cancer	CCLE	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.3056
p.P313A	ACH-000923	Lymphoma	CCLE	STDENVPEP	DEG_COP1_1	320:328	Mutation rewiring degron network	0.1389
p.K234T	ACH-001623	Brain Cancer	CCLE	PETPEET	DEG_SCF_FBW7_1	238:244	Mutation substituting flanking lysine	0.3333
p.S32R	EN	endometrium	COSMIC	ERPELPGLH	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAMD15

UniProt ID: Q9P1V8

Entrez ID: 161394

Protein name: Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAMD15 in