DegronMD

Uniprot ID: Q9P1V8

Source protein: Sterile alpha motif domain-containing protein 15

Source gene: SAMD15

Class: DEG_SCF_FBW7_1

Location: 238:244

E3 ligase: FBXW7

DEGRON score: 0.9321

ASA_SCORE: 111.3286

COIL: 0.9486

CONS_SCORE: 0.4422

DSS_SCORE: 0.8428

HELIX: 0.0413

FCONS_SCORE: 0.9808

RIG_SCORE: 0.5833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D229Y	TCGA-06-5416	GBM	TCGA	PETPEET	DEG_SCF_FBW7_1	0.0833
p.D229Y	DO10880	GBM	ICGC	PETPEET	DEG_SCF_FBW7_1	0.0833
p.E243K	TCGA-55-7727	LUAD	TCGA	PETPEET	DEG_SCF_FBW7_1	0.591
p.E243K	DO24297	LUAD	ICGC	PETPEET	DEG_SCF_FBW7_1	0.591
p.L230P	TCGA-AJ-A3EK	UCEC	TCGA	PETPEET	DEG_SCF_FBW7_1	0.1111
p.L230P	DO41584	UCEC	ICGC	PETPEET	DEG_SCF_FBW7_1	0.1111
p.K237R	TCGA-B6-A0RM	BRCA	TCGA	PETPEET	DEG_SCF_FBW7_1	0.3056
p.K237R	DO3128	BRCA	ICGC	PETPEET	DEG_SCF_FBW7_1	0.3056
p.P241Q	TCGA-D3-A2JP	SKCM	TCGA	PETPEET	DEG_SCF_FBW7_1	0.7035
p.P241Q	DO47407	SKCM	ICGC	PETPEET	DEG_SCF_FBW7_1	0.7035
p.L230I	TCGA-EO-A3B0	UCEC	TCGA	PETPEET	DEG_SCF_FBW7_1	0.1111
p.L230I	DO219773	UCEC	ICGC	PETPEET	DEG_SCF_FBW7_1	0.1111
p.R253K	DO222743	MELA	ICGC	PETPEET	DEG_SCF_FBW7_1	0.0833
p.E242D	SIDM00282	Colorectal Carcinoma	GDSC	PETPEET	DEG_SCF_FBW7_1	0.5647
p.E242D	ACH-000998	Colon/Colorectal Cancer	CCLE	PETPEET	DEG_SCF_FBW7_1	0.5647
p.E242D	CW-2	large_intestine	COSMIC	PETPEET	DEG_SCF_FBW7_1	0.5647
p.E242Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETPEET	DEG_SCF_FBW7_1	0.5633
p.E242Q	ACH-001638	Lymphoma	CCLE	PETPEET	DEG_SCF_FBW7_1	0.5633
p.E242Q	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PETPEET	DEG_SCF_FBW7_1	0.5633
p.K234T	ACH-001623	Brain Cancer	CCLE	PETPEET	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1V8	Sterile alpha motif domain-containing protein 15	DEG_SCF_FBW7_1	238:244	PETPEET	FBXW7	0.9321	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons