DegronMD

Uniprot ID: Q9P1V8

Source protein: Sterile alpha motif domain-containing protein 15

Source gene: SAMD15

Class: DEG_COP1_1

Location: 320:328

E3 ligase: COP1

DEGRON score: 0.9831

ASA_SCORE: 102.3556

COIL: 0.9533

CONS_SCORE: 0.444

DSS_SCORE: 0.7052

HELIX: 0.0247

FCONS_SCORE: 1.1368

RIG_SCORE: 0.6213

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T321A	TCGA-D8-A1XK	BRCA	TCGA	STDENVPEP	DEG_COP1_1	0.6028
p.T321A	DO4749	BRCA	ICGC	STDENVPEP	DEG_COP1_1	0.6028
p.E323Q	TCGA-B5-A11R	UCEC	TCGA	STDENVPEP	DEG_COP1_1	0.5633
p.E323Q	DO43787	UCEC	ICGC	STDENVPEP	DEG_COP1_1	0.5633
p.R318I	TCGA-EO-A22X	UCEC	TCGA	STDENVPEP	DEG_COP1_1	0.2778
p.R318I	DO43907	UCEC	ICGC	STDENVPEP	DEG_COP1_1	0.2778
p.E331D	DO1129	BRCA	ICGC	STDENVPEP	DEG_COP1_1	0.25
p.D314N	TCGA-21-5787	LUSC	TCGA	STDENVPEP	DEG_COP1_1	0.1667
p.D314N	DO26605	LUSC	ICGC	STDENVPEP	DEG_COP1_1	0.1667
p.P313A	ACH-000923	Lymphoma	CCLE	STDENVPEP	DEG_COP1_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1V8	Sterile alpha motif domain-containing protein 15	DEG_COP1_1	320:328	STDENVPEP	COP1	0.9831	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons