DegronMD

Uniprot ID: Q96NA8

Source protein: t-SNARE domain-containing protein 1

Source gene: TSNARE1

Class: DEG_APCC_DBOX_1

Location: 335:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9249

ASA_SCORE: 82.8

COIL: 0.1067

CONS_SCORE: 0.5221

DSS_SCORE: 0.455

HELIX: 0.8918

FCONS_SCORE: 1.2184

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E335G	TCGA-AC-A62X	BRCA	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.6087
p.R341Q	TCGA-BA-A4IF	HNSC	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.6218
p.A349V	TCGA-BR-4184	STAD	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.1667
p.S347L	TCGA-FD-A3SS	BLCA	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.2222
p.K343N	TCGA-OR-A5LT	ACC	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.5806
p.P328L	TCGA-UD-AAC1	MESO	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	0.1389
p.P328L	SIDM00945	Colorectal Carcinoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	0.1389
p.P328L	CL-34	large_intestine	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	0.1389
p.R331G	DO222451	BTCA	ICGC	ERPQLDRLK	DEG_APCC_DBOX_1	0.2222
p.R331G	DO229375	BTCA	ICGC	ERPQLDRLK	DEG_APCC_DBOX_1	0.2222
p.C352S	SIDM00084	Glioblastoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	0.0833
p.C352S	SF295	central_nervous_system	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	0.0833
p.S325I	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	0.0556
p.S325I	ACH-001233	Lung Cancer	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	0.0556
p.S325I	VMRC-LCD	lung	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	0.0556
p.P337S	SIDM00790	Non-Cancerous	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	0.5641
p.R341W	SIDM00225	Melanoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	0.7523
p.C351S	ACH-000376	Brain Cancer	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	0.1111
p.P336S	ACH-002371	Non-Cancerous	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NA8	t-SNARE domain-containing protein 1	DEG_APCC_DBOX_1	335:343	ERPQLDRLK	APC,CDC20,FZR1	0.9249	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons