DegronMD - Q96NA8(TSNARE1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q292H	TCGA-85-6561	LUSC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.3056
p.E335G	TCGA-AC-A62X	BRCA	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6087
p.L282I	TCGA-AX-A06F	UCEC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.L282I	DO41752	UCEC	ICGC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.R280W	TCGA-AX-A1CE	UCEC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R280W	TCGA-BR-8382	STAD	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R280W	DO47925	STAD	ICGC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R280W	DO42280	UCEC	ICGC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R280W	SIDM00850	Gastric Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R280W	AGS	stomach	COSMIC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1944
p.R341Q	TCGA-BA-A4IF	HNSC	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6218
p.A349V	TCGA-BR-4184	STAD	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1667
p.R295W	TCGA-D3-A8GM	SKCM	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.2222
p.L278F	TCGA-DU-7294	LGG	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.1389
p.P288Q	TCGA-ER-A19H	SKCM	TCGA	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.7035
p.S347L	TCGA-FD-A3SS	BLCA	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2222
p.K343N	TCGA-OR-A5LT	ACC	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.5806
p.P328L	TCGA-UD-AAC1	MESO	TCGA	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1389
p.P328L	SIDM00945	Colorectal Carcinoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1389
p.P328L	CL-34	large intestine	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1389
p.R331G	DO222451	BTCA	ICGC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2222
p.R331G	DO229375	BTCA	ICGC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2222
p.T287K	DO229022	LICA	ICGC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.7306
p.C352S	SIDM00084	Glioblastoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0833
p.C352S	SF295	central nervous system	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0833
p.P288L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.7582
p.P288L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation altering degron motif	0.7582
p.L282R	SIDM00296	Small Cell Lung Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.L282R	ACH-002051	Lung Cancer	CCLE	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.L282R	LU-134-A	lung	COSMIC	LGTPSDT	DEG_SCF_FBW7_1	285:291	Mutation rewiring degron network	0.25
p.S325I	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.S325I	ACH-001233	Lung Cancer	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.S325I	VMRC-LCD	lung	COSMIC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.P337S	SIDM00790	Non-Cancerous	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.5641
p.R341W	SIDM00225	Melanoma	GDSC	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.7523
p.C351S	ACH-000376	Brain Cancer	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1111
p.P336S	ACH-002371	Non-Cancerous	CCLE	ERPQLDRLK	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSNARE1

UniProt ID: Q96NA8

Entrez ID: 203062

Protein name: t-SNARE domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSNARE1 in