DegronMD

Uniprot ID: Q96NA8

Source protein: t-SNARE domain-containing protein 1

Source gene: TSNARE1

Class: DEG_SCF_FBW7_1

Location: 285:291

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 61.0714

COIL: 0.8244

CONS_SCORE: 0.6686

DSS_SCORE: 0.5608

HELIX: 0.1536

FCONS_SCORE: 1.1504

RIG_SCORE: 0.644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q292H	TCGA-85-6561	LUSC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.3056
p.L282I	TCGA-AX-A06F	UCEC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.25
p.L282I	DO41752	UCEC	ICGC	LGTPSDT	DEG_SCF_FBW7_1	0.25
p.R280W	TCGA-AX-A1CE	UCEC	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R280W	TCGA-BR-8382	STAD	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R280W	DO47925	STAD	ICGC	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R280W	DO42280	UCEC	ICGC	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R280W	SIDM00850	Gastric Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R280W	AGS	stomach	COSMIC	LGTPSDT	DEG_SCF_FBW7_1	0.1944
p.R295W	TCGA-D3-A8GM	SKCM	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.2222
p.L278F	TCGA-DU-7294	LGG	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.1389
p.P288Q	TCGA-ER-A19H	SKCM	TCGA	LGTPSDT	DEG_SCF_FBW7_1	0.7035
p.T287K	DO229022	LICA	ICGC	LGTPSDT	DEG_SCF_FBW7_1	0.7306
p.P288L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	0.7582
p.P288L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LGTPSDT	DEG_SCF_FBW7_1	0.7582
p.L282R	SIDM00296	Small Cell Lung Carcinoma	GDSC	LGTPSDT	DEG_SCF_FBW7_1	0.25
p.L282R	ACH-002051	Lung Cancer	CCLE	LGTPSDT	DEG_SCF_FBW7_1	0.25
p.L282R	LU-134-A	lung	COSMIC	LGTPSDT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NA8	t-SNARE domain-containing protein 1	DEG_SCF_FBW7_1	285:291	LGTPSDT	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons