DegronMD

Uniprot ID: Q14767

Source protein: Latent-transforming growth factor beta-binding protein 2

Source gene: LTBP2

Class: DEG_APCC_DBOX_1

Location: 769:777

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6908

ASA_SCORE: 90.5556

COIL: 0.704

CONS_SCORE: 0.4739

DSS_SCORE: 0.6004

HELIX: 0.0833

FCONS_SCORE: 1.1308

RIG_SCORE: 0.7369

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A768E	TCGA-37-3792	LUSC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.3056
p.A768E	DO27192	LUSC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.3056
p.Q771H	TCGA-55-7907	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.647
p.Q771H	DO25396	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.647
p.T777M	TCGA-55-8506	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.6312
p.T777M	DO45390	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.6312
p.G762V	TCGA-78-7540	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.G762V	DO23810	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.V776I	TCGA-AA-3692	COAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.5965
p.V776I	DO9474	COAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.5965
p.R759M	TCGA-AX-A2HC	UCEC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.0556
p.R759M	DO41572	UCEC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.0556
p.T779S	TCGA-DF-A2KU	UCEC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.2778
p.T779S	DO223286	UCEC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.2778
p.P787H	TCGA-EE-A2MK	SKCM	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.0556
p.P787H	DO38177	SKCM	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.0556
p.G762R	TCGA-EE-A3J5	SKCM	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.G762R	DO47331	SKCM	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.G784R	DO223369	CLLE	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.G784R	DO229245	THCA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1389
p.R774W	DO233156	GACA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.7523
p.P772T	DO228974	LICA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.5919
p.L764M	DO229029	LICA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1944
p.T785I	DO220886	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.1111
p.P772L	DO220906	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.6471
p.D778N	DO222390	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	0.3056
p.I786V	SIDM00337	Melanoma	GDSC	ERQPLRVVT	DEG_APCC_DBOX_1	0.0833
p.I786V	ACH-000450	Skin Cancer	CCLE	ERQPLRVVT	DEG_APCC_DBOX_1	0.0833
p.I786V	MEL-HO	skin	COSMIC	ERQPLRVVT	DEG_APCC_DBOX_1	0.0833
p.R770M	SIDM00228	Thyroid Gland Carcinoma	GDSC	ERQPLRVVT	DEG_APCC_DBOX_1	0.8632
p.R770M	ACH-000897	Thyroid Cancer	CCLE	ERQPLRVVT	DEG_APCC_DBOX_1	0.8632

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERQPLRVVT

Degron related mutations and impact score

Drug responses associated with LTBP2 mutations

All proteins holding degron of ERQPLRVVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14767	Latent-transforming growth factor beta-binding protein 2	DEG_APCC_DBOX_1	769:777	ERQPLRVVT	APC,CDC20,FZR1	0.6908	More...