DegronMD - Q14767(LTBP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A768E	TCGA-37-3792	LUSC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.3056
p.A768E	DO27192	LUSC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.3056
p.Q771H	TCGA-55-7907	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.647
p.Q771H	DO25396	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.647
p.T777M	TCGA-55-8506	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.6312
p.T777M	DO45390	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.6312
p.G762V	TCGA-78-7540	LUAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.G762V	DO23810	LUAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.V776I	TCGA-AA-3692	COAD	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.5965
p.V776I	DO9474	COAD	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.5965
p.R759M	TCGA-AX-A2HC	UCEC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.R759M	DO41572	UCEC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.T779S	TCGA-DF-A2KU	UCEC	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.2778
p.T779S	DO223286	UCEC	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.2778
p.A154V	TCGA-DK-A2I4	BLCA	TCGA	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.25
p.A154V	DO465	BLCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.25
p.P787H	TCGA-EE-A2MK	SKCM	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.P787H	DO38177	SKCM	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.G762R	TCGA-EE-A3J5	SKCM	TCGA	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.G762R	DO47331	SKCM	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.G152V	TCGA-ER-A19T	SKCM	TCGA	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.3056
p.G152V	DO51251	SKCM	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.3056
p.A139T	TCGA-SJ-A6ZI	UCEC	TCGA	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.A139T	DO219784	UCEC	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.G784R	DO223369	CLLE	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.G784R	DO229245	THCA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1389
p.R774W	DO233156	GACA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.7523
p.P155S	DO233628	GACA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.2222
p.P158L	DO233791	GACA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.P772T	DO228974	LICA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.5919
p.L764M	DO229029	LICA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1944
p.P158Q	DO229028	LICA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.P158Q	DO229006	LICA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.T785I	DO220886	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.1111
p.P772L	DO220906	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.6471
p.D778N	DO222390	MELA	ICGC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.3056
p.T157P	DO219881	SKCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.T157P	ACH-001331	Head and Neck Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.R135Q	DO229272	THCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.0556
p.R137L	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R137L	ACH-000840	Lung Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R137L	HCC-366	lung	COSMIC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.I786V	SIDM00337	Melanoma	GDSC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0833
p.I786V	ACH-000450	Skin Cancer	CCLE	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0833
p.I786V	MEL-HO	skin	COSMIC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0833
p.R770M	SIDM00228	Thyroid Gland Carcinoma	GDSC	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.8632
p.R770M	ACH-000897	Thyroid Cancer	CCLE	ERQPLRVVT	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.8632
p.A139V	ACH-000581	Gastric Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.A139V	NCI-SNU-16	stomach	COSMIC	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1667
p.P140S	ACH-001719	Ovarian Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LTBP2

UniProt ID: Q14767

Entrez ID: 4053

Protein name: Latent-transforming growth factor beta-binding protein 2 (LTBP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LTBP2 in