DegronMD

Uniprot ID: Q14767

Source protein: Latent-transforming growth factor beta-binding protein 2

Source gene: LTBP2

Class: DEG_SCF_FBW7_1

Location: 145:151

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 100.3714

COIL: 0.9606

CONS_SCORE: 0.3608

DSS_SCORE: 0.83

HELIX: 0.0193

FCONS_SCORE: 0.9718

RIG_SCORE: 0.5923

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A154V	TCGA-DK-A2I4	BLCA	TCGA	LGTPQRS	DEG_SCF_FBW7_1	0.25
p.A154V	DO465	BLCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.25
p.G152V	TCGA-ER-A19T	SKCM	TCGA	LGTPQRS	DEG_SCF_FBW7_1	0.3056
p.G152V	DO51251	SKCM	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.3056
p.A139T	TCGA-SJ-A6ZI	UCEC	TCGA	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.A139T	DO219784	UCEC	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.P155S	DO233628	GACA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.2222
p.P158L	DO233791	GACA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.1389
p.P158Q	DO229028	LICA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.1389
p.P158Q	DO229006	LICA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.1389
p.T157P	DO219881	SKCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.T157P	ACH-001331	Head and Neck Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.R135Q	DO229272	THCA	ICGC	LGTPQRS	DEG_SCF_FBW7_1	0.0556
p.R137L	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LGTPQRS	DEG_SCF_FBW7_1	0.1111
p.R137L	ACH-000840	Lung Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	0.1111
p.R137L	HCC-366	lung	COSMIC	LGTPQRS	DEG_SCF_FBW7_1	0.1111
p.A139V	ACH-000581	Gastric Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.A139V	NCI-SNU-16	stomach	COSMIC	LGTPQRS	DEG_SCF_FBW7_1	0.1667
p.P140S	ACH-001719	Ovarian Cancer	CCLE	LGTPQRS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14767	Latent-transforming growth factor beta-binding protein 2	DEG_SCF_FBW7_1	145:151	LGTPQRS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons